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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
adsorption / desorption
Remarks:
other: adsorption coefficient calculated from the partiton coefficient
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Study period:
September 23rd to December 23rd 1996
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study was conducted according to an OECD Method and in accordance with GLP. The study material is well characterized.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1996
Report date:
1997

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: Adsorption calculated from the partition coefficient determinded in accordance with OECD 117
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
424-660-8
EC Name:
-
Cas Number:
224631-15-6
Molecular formula:
Hill formula: C18H26N4O5S CAS formula: C18H26N4O5S
IUPAC Name:
2,5-dioxopyrrolidin-1-yl (2S)-3-methyl-2-{[methyl({[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl})carbamoyl]amino}butanoate
Radiolabelling:
no

Study design

Batch equilibrium or other method

Analytical monitoring:
yes

Results and discussion

Adsorption coefficient
Type:
Koc
Remarks:
calculated from the partition coefficient results for A-133816.0
Value:
1 585

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The adsorption coeffcient of the components of the test material have been determined to be 1585.


The abiotic hydrolysis for A-133816.0 could not be readily established. The investigations undertaken showed that A-133816.0 could not exist in its ready state in an aquatic environment with complete breakdown of the material to its breakdon products with 1 h (at 20 oC)