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EC number: -
CAS number: -
In an acute oral toxicity study performed
according to the OECD test guideline No. 420 and in compliance with GLP,
groups of fasted, eight to twelve weeks of age Wistar (RccHanTM:WIST)
female rats were given a single oral dose of ST 15 C 12.
Following a sighting test using one animal
at a dose level of 2000 mg/kg bw, an additional four fasted female
animals were given a single oral dose of test item, at the same dose
level. Clinical signs and bodyweight development were monitored during
the study. All animals were subjected to gross necropsy.
Oral LD50 Females > 2000 mg/kg
There were no deaths during the study.
Hunched posture and ataxia were noted in four animals. There were no
signs of systemic toxicity noted in the initial treated animal
All animals showed expected gains in
bodyweight. No abnormalities were noted at necropsy.
Under the experimental conditions of this
study, the test item is not classified according to Regulation (EC) No.
1272/2008 (CLP) and to GHS since the Rat Oral LD50 (females) > 2000
mg/kg bw and no mortality or any adverse effects were observed.
This study is considered as acceptable and
satisfies the requirement for acute oral toxicity endpoint.
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