Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-235-5
CAS number: 13703-82-7
A study on acute oral toxicity in the
rat has been conducted with the test item according to OECD Guideline
420 and in compliance with GLP criteria. Five female rats (nulliparous
and non-pregnant) of the Wistar strain with an initial body weight of
180 to 193g were used as test animals. The rats were deprived of food
during the night immediately before dosing and for approximately 3-4
hours after dosing. The test item was injected into each animal by a
gavage whereby the dose was 2000 mg / kg body weight. No rats were used
as a control group. The observation period was 14 days and ended with
the euthanization of the rats on day 14. Clinical observations were made
30 minutes, 1, 2 and 4 hours after dosing and then daily for 14 days.
Morbidity and mortality checks were made twice daily at working days and
once daily at weekends and public holidays. There were no deaths during
the study period and no signs of systematic toxicity were noted during
the observation period. Body weight was recorded on day 0, day 7 and on
day 14: all animals gained body weight during the study period. The mean
body weight of the 5 test animals was 185.6 g at day 1 and increased to
224 g at day 14. Each animal was subject to gross necropsy which
consisted of an external examination and opening of the abdominal and
thoracic cavities. No abnormalities were noted at necropsy.
An acute oral median LD50
of the test item in the female Wistar strain rat was found to be greater
than 2000 mg/kg body weight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again