Registration Dossier
Registration Dossier
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EC number: 247-761-7 | CAS number: 26530-20-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
- Reference Type:
- other: Assessment as woodpreservative under Regulation (EU) 528/2012
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Guideline:
- other: GPMT
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- GPMT test results available
Test material
- Reference substance name:
- 2-octyl-2H-isothiazol-3-one
- EC Number:
- 247-761-7
- EC Name:
- 2-octyl-2H-isothiazol-3-one
- Cas Number:
- 26530-20-1
- Molecular formula:
- C11H19NOS
- IUPAC Name:
- 2-octyl-2H-isothiazol-3-one
- Reference substance name:
- dihydrogen oxide
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- dihydrogen oxide
- Test material form:
- liquid
Constituent 1
impurity 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Key result
- Reading:
- other: strong sensitiser
- Group:
- test chemical
- Dose level:
- unknown
- No. with + reactions:
- 10
- Total no. in group:
- 15
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
