Registration Dossier
Registration Dossier
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EC number: 946-788-8 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
- Principles of method if other than guideline:
- A group of male white rats was treated with a single dose of 5000 mg/kg b.w. by dermal route. Gauze pads with the test substance were applied for 4 hours on the skin of the back of animals and the treated skin areas were not washed after the exposure.
- GLP compliance:
- no
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- AcidBrown360
- IUPAC Name:
- AcidBrown360
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- Area of exposure: shaved skin of the back of animals
- Type of wrap if used: gauze pad
REMOVAL OF TEST SUBSTANCE
The treated skin areas were not washed after the exposure. - Duration of exposure:
- 4 hours
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- n.a
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified according to the CLP Regulation (EC 1272/2008)
- Conclusions:
- LD50 (dermal) > 5000 mg/kg b.w
- Executive summary:
The dermal acute toxicity study was performed according to an internal method: a group of male white rats was treated with a single dose of 5000 mg/kg b.w. by dermal route. Gauze pads with the test substance were applied for 4 hours on the skin of the back of animals and the treated skin areas were not washed after the exposure.
The acute dermal LD50 of the substance in rats was found to be more than 5000 mg/kg b.w.
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