p,p',p''-tris(dimethylamino)trityl alcohol

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test results performed using standard test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

GLP compliance:

no

Type of method:

flask method

Key result

Water solubility:

0.64 mg/L

Temp.:

25 °C

Remarks on result:

other: other details are not known

PRELIMINARY TEST AT 96 h

Concentration obtained (mg/L)		Average	Absorbance	Average	Total Dilution factor(if any)	Water Solubility Value by Standard Curve (mg/L)	Average
R1	1.115	1.111	0.206	0.206	10	11.15	11.11 mg/L
R2	1.106		0.205		10	11.06

CONFIRMATORY TEST AT 24, 48 AND 72 h

Sample stirring (h)	Concentration obtained		Average	Absorbance	Average	Dilution factor	Water Solubility value obtained (mg/L)	Average
24 h	R1	0.609	0.608	0.113	0.113	-	0.609	0.608
	R2	0.608		0.113			0.608
48 h	R1	0.634	0.655	0.117	0.121	-	0.634	0.655
	R2	0.677		0.125			0.677
72 h	R1	0.647	0.650	0.119	0.120	-	0.647	0.650
	R2	0.654		0.121			0.654

pH
Preliminary Test		Confirmatory Test
96			24 h	48 h	72 h
R1	4.17	R1	4.92	4.32	4.53
R2	4.20	R2	4.87	4.47	4.64

CALCULATION

The water solubility for 24 h, 48 h and 72 h was calculated as follows: Mean water solubility value for 24 h + 48 h + 72 h run sample.

= (0.608 + 0.655 + 0.650)/3

= 0.64mg/L

Conclusions:

The study was conducted to determine the solubility of test chemical in ultra-pure water, according to the OECD guideline 105 (Adopted by the Council on 27th July 1995) and OECD 101(Adopted: 12 May 1981) and was determined to be 0.64 mg/L at 25 ± 2°C.

Executive summary:

The study was conducted to determine the solubility of test chemical in ultra-pure water, according to the OECD guideline 105 (Adopted by the Council on 27th July 1995) and OECD 101(Adopted: 12 May 1981). Test was conducted at 25±2 °C in two stages; preliminary testfor 96 h, followed by confirmatory test for 24 h, 48 h and 72 h in replicates. The final water solubility value was calculated based on average of the individual values obtained after 24 h, 48 h and 72 h. The difference between the average values in three vessels was not observed more than 15%. The water solubility value was determined to be 0.64 mg/L at 25 ± 2°C.

Description of key information

The study was conducted to determine the solubility of test chemical in ultra-pure water, according to the OECD guideline 105 (Adopted by the Council on 27th July 1995) and OECD 101(Adopted: 12 May 1981) and was determined  to be 0.64 mg/L at 25 ± 2°C.

Key value for chemical safety assessment

Water solubility:

0.64 mg/L

at the temperature of:

25 °C

Additional information

The study was conducted to determine the solubility of test chemical in ultra-pure water, according to the OECD guideline 105 (Adopted by the Council on 27th July 1995) and OECD 101(Adopted: 12 May 1981). Test was conducted at 25±2 °C in two stages; preliminary testfor 96 h, followed by confirmatory test for 24 h, 48 h and 72 h in replicates. The final water solubility value was calculated based on average of the individual values obtained after 24 h, 48 h and 72 h. The difference between the average values in three vessels was not observed more than 15%. The water solubility value was determined to be0.64 mg/L at 25 ± 2°C.