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Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer-reviewed journal

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Monographs on fragrance raw materials: Amyl cinnamic aldehyde
Author:
D.L.J.Opdyke
Year:
1973
Bibliographic source:
Food and Cosmetics Toxicology Volume 11, Issue 5, October 1973, Pages 855-856
Reference Type:
secondary source
Title:
Initial Risk-Based Prioritization of High Production Volume (HPV) Chemicals Cinnamyl Derivatives Category.
Author:
U. S. Environmental Protection Agency (EPA) Office of Pollution Prevention and Toxics (OPPT) Risk Assessment Division (RAD)
Year:
2009
Bibliographic source:
U.S. Environmental Protection Agency Risk-Based Prioritization Document, April 2009.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: refer below
Principles of method if other than guideline:
The acute toxicity study was examined to evaluate the toxic effects of administration of amyl cinnamic aldehyde (2-benzylideneheptanal) (CAS No. 122-40-7) in rabbit by the dermal route.
GLP compliance:
not specified
Test type:
other: No data available
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-benzylideneheptanal
EC Number:
204-541-5
EC Name:
2-benzylideneheptanal
Cas Number:
122-40-7
Molecular formula:
C14H18O
IUPAC Name:
2-benzylideneheptanal
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): amylcinnamaldehyde
- Molecular formula : C14H18O
- Molecular weight: 202.2952 g/mol
- Smiles notation: c1(\C=C(\CCCCC)C=O)ccccc1
- InChl: 1S/C14H18O/c1-2-3-5-10-14(12-15)11-13-8-6-4-7-9-13/h4,6-9,11-12H,2-3,5,10H2,1H3/b14-11-
- Substance type: organic
- Physical state: Liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): Amyl cinnamic aldehyde (2-benzylideneheptanal)
- Molecular formula: C14H18O
- Molecular weight : 202.2952 g/mole
- Substance type: Organic
- Physical state:Liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: No data available
- Females (if applicable) nulliparous and non-pregnant: No data available
- Age at study initiation: No data available
- Weight at study initiation: No data available
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): No data available
- Water (e.g. ad libitum): No data available
- Acclimation period: No data available

ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%): No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available

IN-LIFE DATES: From: To: No data available

Administration / exposure

Type of coverage:
other: dermal
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
No data available
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
4 rabbits/sex
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: No data available
- Frequency of observations and weighing: No data available
- Necropsy of survivors performed: No data available
- Other examinations performed: No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: There was no evidence of toxicity at the dose tested.
Mortality:
No mortality observed upto 2000.0 mg/kg bw
Clinical signs:
other: There was no evidence of toxicity at the dose tested.
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: not classified based on CLP criteria
Conclusions:
The acute dermal median lethal dose (LD50) was considered to be greater than 2000 mg/kg bw (>2000 mg/kg bw). When rabbits were treated with amyl cinnamic aldehyde (2-benzylideneheptanal) (CAS No. 122-40-7) by dermal application.






Executive summary:

The acute toxicity study was examined to evaluate the toxic effects of administration of amyl cinnamic aldehyde (2-benzylideneheptanal) (CAS No. 122-40-7) in rabbit by the dermal route. Four rabbits were administered amyl cinnamic aldehyde (2-benzylideneheptanal)  dermally at 2000 mg/kg bw. No evidence of toxicity was seen. No mortality was observed. hence the acute dermal median lethal dose (LD50) was considered  to be greater than 2000 mg/kg bw (>2000 mg/kg bw). When rabbits were treated with amyl cinnamic aldehyde (2-benzylideneheptanal) (CAS No. 122-40-7) by dermal application.