2-benzylideneheptanal

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

data is from J-check authoritative databases.

Qualifier:

according to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

Principles of method if other than guideline:

short term toxicity study on the fish of the chemical alpha-Amyl cinnamaldehyde.

GLP compliance:

not specified

Specific details on test material used for the study:

- Name of test material: α-Amyl Cinnamaldehyde
- Molecular formula : C14H18O
- Molecular weight : 202.2952 g/mol
- Substance type: Organic
- Physical state: No data
- Purity: No data
- Impurities: No data

Analytical monitoring:

not specified

Details on sampling:

No data

Vehicle:

not specified

Details on test solutions:

no data

Test organisms (species):

not specified

Details on test organisms:

no data

Test type:

static

Water media type:

freshwater

Total exposure duration:

96 h

Remarks on exposure duration:

no data

Post exposure observation period:

No data

Hardness:

No data

Test temperature:

No data

pH:

No data

Dissolved oxygen:

No data

Salinity:

No data

Conductivity:

No data

Nominal and measured concentrations:

nominal

Details on test conditions:

No data

Reference substance (positive control):

not specified

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

0.91 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Details on results:

No data

Results with reference substance (positive control):

No data

Reported statistics and error estimates:

No data

Validity criteria fulfilled:

not specified

Conclusions:

Based on the mortality of the fish due to alpha-Amyl cinamaldehyde, the LC50 is 0.91mg/l.

Executive summary:

Short term toxic effect on the fish was observed by using the chemical alpha-Amyl cinnamaldehyde, by using the static method with the 96hrs of exposure period. The study was carried out as according to the OECD guideline.

 

Based on the 0.91mg/l LC50 value, it can be concluded that the test chemical alpha-Amyl cinnamaldehyde can be considered as toxic to the aquatic organism fish at environment revelent concentration and thus can be considered to be classified in aquatic acute category 1 as per the CLP classification criteria.

Description of key information

Based on the experimental key study (J-check authoritative databases, 2016) short term toxicity to fish was observed by using the chemical alpha-Amyl cinnamaldehyde(122 -40 -7) 2 -benzylideneheptanal,by using the static method with the 96hrs of exposure period. The study was carried out as according to the OECD guideline.Based on the 0.91mg/l LC50 value, it can be concluded that the test chemical alpha-Amyl cinnamaldehyde can be considered as toxic to the aquatic organism fish at environment revelent concentration and thus can be considered to be classified in aquatic acute category 1 as per the CLP classification criteria.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

0.91 mg/L

Additional information

Based on the various experimental data and prediction data by using the EPI suite ECOSAR for the target chemical have been reviewed to determine the toxic nature of alpha-Amyl cinnamaldehyde (122-40-7), IUPAC name 2-benzylideneheptanal on the growth of fishes. The studies are as mentioned below:

 

Based on the experimental key study (J-check authoritative databases, 2016) short term toxicity to fish was observed by using the chemical alpha-Amyl cinnamaldehyde (122 -40 -7) 2 -benzylideneheptanal, by using the static method with the 96hrs of exposure period. The study was carried out as according to the OECD guideline. Based on the 0.91mg/l LC50 value, it can be concluded that the test chemical alpha-Amyl cinnamaldehyde can be considered as toxic to the aquatic organism fish at environment revelent concentration and thus can be considered to be classified in aquatic acute category 1 as per the CLP classification criteria.

 

Similarly in another supporting study for alpha amyl cinnamaldeyde (122-40-7), in the RIFM report, 2015 Short term toxic effect on the fish was observed by using the chemical alpha-Amyl cinnamaldehyde, by using the static method with the 96hrs of exposure period. Study performed as per the OECD guideline. Based on the LC100 i.e. 3 mg/l value, it can be concluded that the test chemical alpha-Amyl cinnamaldehyde can be considered as toxic to the aquatic organism fish at environment relevant concentration and thus can be considered to be classified in aquatic chronic category 2 as per the CLP classification criteria.

 

In another supporting study for target chemical (FFHPVC), 2005 Short term toxicity effect on the zebrafish was observed by using the chemical alpha-Amyl cinnamaldehyde. Study performed by using semi static method with the 96hrs of exposure period. Based on the 3.14 mg/l value, it can be concluded that the test chemical alpha-Amyl cinnamaldehyde can be considered as toxic to the aquatic organism fish at environment relevant concentration and thus can be considered to be classified in aquatic chronic category 2 as per the CLP classification criteria.

 

Based on the prediction done by EPI suite, ECOSAR version 1.1, for alpha-Amyl cinnamaldehyde (122-40-7) on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to fish was predicted. On the basis of EPI suite, ECOSAR version 1.1, the LC 50 value for short term toxicity to fish was predicted to be 1.344 mg/l for CAS name alpha amyl cinnamaldehyde in 96 hrs. Based on this value it can be concluded that the substance is considered to be toxic to aquatic environment and can be classified in aquatic chronic 2 category as per the criteria mentioned in CLP regulation.

 

The experimental key study classify the chemical in acute category 1, but remaining studies support chronic category 2. As the small amount of chemical was toxic to the growth of fishes thus by considering the key study alpha-Amyl cinnamaldehyde classified in acute 1 category.

 

Based on the data available for the target chemical alpha-Amyl cinnamaldehyde (122-40-7), IUPAC name 2-benzylideneheptanal from various databases and prediction models, alpha-Amylcinnamaldehyde exhibit toxicity on the growth of fishes. Hence the test chemical is likely to classify as toxic and consider acute 1 as per the criteria mentioned in CLP regulation.