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EC number: 460-230-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 02 August 2012 - 07 September 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant study conducted in accordance with international guidelines.
- Justification for type of information:
- 1. HYPOTHESIS FOR THE ANALOGUE APPROACH
Common functional groups and similar composition.
EP-4000s and the registered substance are very similar. They are UVBC substances and both are oligomeric reaction products of 4,4'-propane-2,2-diyldiphenol and 2-methyloxirane and 2-(chloromethyl)oxirane where constituents are structurally related. EP-4000s contains less than 0.1% monochlorinated constituents while the registered substance contains approximately 10% monochlorinated constituents. As these are otherwise structurally similar to other constituents it can be reasonably expected that EP-4000s and the registered substance will have essentially the same properties.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
EP4000s:
Purity 79.7-90%, 3 main components F, E, C
Impurities:
5 known by-products 18%
6 unknown impurities 2.4%
Water 0.1%
Chlorinated impurities <0.1%
Aliphaticdiol diglycidyl ether:
Purity 92.57%, 3 main components F, E, C
Impurities:
5 known by-products (same identity as EP-400s) 14.37%
Water none
Two new impurities (I and J) 10.48% in total
Further details are provided in Section 13 Assessment Reports
3. ANALOGUE APPROACH JUSTIFICATION
EP-4000s was tested and found to be not readily biodegradable. The introduction of one chlorine atom to the chemical structure will not affect the biodegradation properties as the molecular backbone of the components are still the same. Furthermore, there was 0% biodegradation over 28 days for Aliphaticdiol diglycidyl ether, so even if the chlorinated portion of the mixture did biodegrade completely, the 60% degradation criteria would still not be passed.
Conclusion – no new information would be gained by test Aliphaticdiol diglycidyl ether for ready biodegradability – accept classification as not readily biodegradable.
4. DATA MATRIX
Not applicable – read across based on similar composition. - Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): A sample of activated sludge was obtained from sewage treatment works which treats predominantly domestic waste. At the time of collection, the sludge was sieved (1 mm2) then transported to the laboratory and left to stand for approximately 30 minutes to allow the sewage solids to settle.
A portion of the supernatant was removed and the sludge aerated until required.
- Preparation of inoculum for exposure: Aliquots (10 mL) of the sludge were filtered and dried again at approximately 105°C for one hour, allowed to cool in a desiccator and reweighed. The mixed liquor suspended solids (MLSS) content of the sludge was then determined and the volume required to give a solids level of 30 mg/L in test cultures was calculated. This was added to bottles one day before test initiation to allow a period of ageing.
- Concentration of sludge: 30 mg/L
- Type and size of filter used, if any: Whatman GF/C filters - Duration of test (contact time):
- 28 d
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: mineral salts prepared from solutions of:
Potassium dihydrogen phosphate
di-Potassium hydrogen phosphate
di-Sodium monohydrogen phosphate dihydrate
Ammonium chloride
Magnesium sulphate heptahydrate
Calcium chloride dihydrate
Iron (III) chloride hexahydrate
- Test temperature: 20.0 to 24.4 °C
- pH: at the start of the test - between 7.36 and 7.38, at the end of the test - between 7.38 and 7.56
- pH adjusted: no
TEST SYSTEM
- Culturing apparatus: amber glass culture bottles
- Number of culture flasks/concentration: 2 for the blank-control, 2 for the test substance, 1 for the reference substance and 1 for the inhibition assay
- Method used to create aerobic conditions: stirring
- Measuring equipment: respirometer
- Test performed in open system: no
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes - Reference substance:
- benzoic acid, sodium salt
- Test performance:
- The blank-corrected oxygen demanded by the culture containing the reference substance had achieved 16.40 mgO2/500 mL or 66% of the ThOD (25 mgO2/500 mL) after 3 days of incubation and 22.04 mgO2/500 mL or 88% by Day 28.
In the presence of EP-4000S, degradation of sodium benzoate had achieved 65% by Day 4.
Cumulative levels of oxygen consumption by the controls after 28 days (14.20 and 17.26 mgO2/500 mL, equivalent to 28.40 and 34.52 mgO2/L) were considered to be acceptable for this assay system.
There was no significant oxygen consumption in mixtures containing EP-4000S above that of the control mixtures during the test (at most, 0.03 mgO2/500 mL).
Substances are considered to be readily biodegradable in this type of test if oxygen consumption is equal to or greater than 60% of the ThOD of the mixtures within ten days of the consumption achieving 10%. Therefore, EP-4000S was not considered to be readily biodegradable under the conditions of this test.
These results confirm that EP-4000S was not inhibitory to the activity of the microbial inoculum and that the test was valid. - Parameter:
- % degradation (O2 consumption)
- Value:
- ca. 0
- Sampling time:
- 28 d
- Details on results:
- There was no significant oxygen consumption in mixtures containing EP-4000S above that of the control mixtures during the test (at most, 0.03 mgO2/500 mL).
Substances are considered to be readily biodegradable in this type of test if oxygen consumption is equal to or greater than 60% of the ThOD of the mixtures within ten days of the consumption achieving 10%. Therefore, EP-4000S was not considered to be readily biodegradable under the conditions of this test. - Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Not readily biodegradable
Reference
Description of key information
Aliphaticdiol diglycidyl etheris not considered to be readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
A ready biodegradability screening test was conducted (Huntingdon Life Sciences,2012) to assess the potential for EP-4000S to be degradaed over a 28 -day period. The study was performed according to OECD test guideline 301F (Ready Biodegradability, Manometric Respirometry Test) and in compliance with GLP. There was no significant oxygen consumption in mixtures containing EP-4000S above that of the control mixtures during the test (at most 0.03 mgO2/500 mL). Substances are considered to be readily biodegradable in this type of test if oxygen consumption is equal to or greater than 60% of the ThOD of the mixtures within ten days of the consumption achieving 10%. Therefore, EP-4000S was not considered to be readily biodegradable under the conditions of this test.
The result of not readily biodegradable for EP-4000s will be read across to Aliphaticdiol diglycidyl ether.
Justification for read across justification - EP-4000s and Aliphaticdiol diglycidyl ether are very similar substances. They are UVBC subtances and both are oligomeric reaction products of 4,4'-propane-2,2-diyldiphenol and 2-methyloxirane and 2-(chloromethyl)oxirane where consituents are structurally related. EP-4000s contains less than 0.1% monochlorinated consitiuents while Aliphaticdiol diglycidyl ether contains approximately 10% monochlorinated constituents, but as these are otherwise structurally similar to other constituents it can be reasonably expected that EP-4000s and Aliphaticdiol diglycidyl ether will have essentially the same properties. EP-4000s was tested and found to be not readily biodegradable. The introduction of one chlorine atom to the chemical structure will not affect the biodegradation properties as the molecular backbone of the components are still the same. Furthermore, there was 0% biodegradation over 28 days for EP-4000s, so even if the chlorinated portion of the mixture did biodegrade completely, the 60% degradation criteria would still not be passed.
Conclusion – no new information would be gained by test Aliphaticdiol diglycidyl ether for ready biodegradability – accept classification as not readily biodegradable.
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