Registration Dossier
Registration Dossier
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EC number: 204-112-2 | CAS number: 115-86-6
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: early study , few animals. Also assessed by OECD.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 956
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Study to determine the neurotoxicity of TPP in hens.
- GLP compliance:
- no
Test material
- Reference substance name:
- Triphenyl phosphate
- EC Number:
- 204-112-2
- EC Name:
- Triphenyl phosphate
- Cas Number:
- 115-86-6
- Molecular formula:
- C18H15O4P
- IUPAC Name:
- triphenyl phosphate
Constituent 1
Test animals
- Species:
- other: hen
- Strain:
- other: leghorn
- Sex:
- male
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- other: undiluted
- Doses:
- 500 mg/kg
- No. of animals per sex per dose:
- 2
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- other: other
- Effect level:
- > 500 mg/kg bw
- Gross pathology:
- None observed.
Any other information on results incl. tables
No signs of neurotoxicity developed in either cockerel.
There was no histological evidence of degeneration in the brain, cord, or sciatic nerves.
Applicant's summary and conclusion
- Executive summary:
Two cockerels administered TPP vic s.c route at a dose of 500 mg/kg (once) showed no signs of neurotoxicity. There was no evidence of degneration in the brain, cord or sciatic nerves.
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