Registration Dossier
Registration Dossier
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EC number: 204-112-2 | CAS number: 115-86-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Short report, few details. Also assessed by OECD
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Method: other: as described in 16 CFR 1500.40
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Triphenyl phosphate
- EC Number:
- 204-112-2
- EC Name:
- Triphenyl phosphate
- Cas Number:
- 115-86-6
- Molecular formula:
- C18H15O4P
- IUPAC Name:
- triphenyl phosphate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- This study was conducted according to US Federal Hazardous Substances Act Regulations study guideline 16 CFR 1500.40. 5 rabbits were tested with intact skin and 5 with abraded skin. Observation period of 14 days.
- Doses:
- 10000 mg/kg
- No. of animals per sex per dose:
- 10
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Mortality:
- None
- Clinical signs:
- other: No data
- Gross pathology:
- No data
Any other information on results incl. tables
MORTALITY: none
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Conclusions:
- Dermal LD50 is > 10,000 mg/kg body weight.
- Executive summary:
2 groups of 5 albino rabbits were treated each with a dose of 10 000 mg/kg body weight on either intact or abraded skin. No adverse effects nor mortality were observed during 14 -days post-exposure. The LD50 is >10,000 mg/kg body weight.
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