2-butoxyethanol

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Recent, well documented study published in open literature

Data source

Reference

Reference Type:

publication

Title:

Higher prevalence of breathlessness in elderly exposed to indoor aldehydes and VOCs in a representative sample of French dwellings

Author:

Bentayeb M, Billionnet C, Baiz N, Derbez M, Kirchner S, Annesi-Maesano I

Year:

2013

Bibliographic source:

Respiratory Medicine 107, 1598-1607

Materials and methods

Endpoint addressed:

other: breathlessness

Principles of method if other than guideline:

To determine the respiratory effects of indoor exposures to aldehydes and VOCs, including butoxyethanol, as objectively measured using passive samplers, in elderly living in a population-based representative sample of French dwellings.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-butoxyethanol

EC Number:

203-905-0

EC Name:

2-butoxyethanol

Cas Number:

111-76-2

Molecular formula:

C6H14O2

IUPAC Name:

2-butoxyethanol

Method

Ethical approval:

not applicable

Details on study design:

Total population N=1012 (<65: 868, >65: 144).

Exposure assessment:

measured

Details on exposure:

TYPE OF EXPOSURE: Indoor air.

TYPE OF EXPOSURE MEASUREMENT: Area air sampling. VOCs were collected onto Carbograph four adsorbents (Radiello, Fondazione Salvatore Maugeri (FSM)). Adsorbed VOCs were extracted through thermodesorption and analyzed by GC/FID-MS. 567 dwellings were assessed over a period of one week.

Results and discussion

Results:

Indoor levels of 2-butoxyethanol were detectable but very low. For the under 65yrs old population cohort, the average measured value was 1.5ug/m3 (95% CI=0-6.5ug/m3, max value detected 40ug/m3. For the over 65yrs old population cohort, the average measured value was 0.6ug/m3 (95% CI=0-4.5ug/m3, max value detected 48ug/m3. No correlation was found between the reported incidence of breathlessness in the population and measured levels of 2-butoxyethanol.

Applicant's summary and conclusion

Executive summary:

In a study to measure the levels of indoor air concentrations of a number of volatile organic compounds,and the reported incidence of breathlessness symptoms in the elderly, no correlation was found for 2 -butoxyethanol.