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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Peer reviewed publication utilizing non-standard in vitro methods using diester form of DINP, which is not generally detected in systemic circulation following in vivo exposures.

Data source

Reference
Reference Type:
publication
Title:
A novel transcriptomics based in vitro method to compare and predict hepatotoxicigy based on mode of action
Author:
De Abrew N., Overmann G., Adams R., Tiesman J., Dunavent J., Shan Y., Carr G., Daston G., Naciff J.
Year:
2015
Bibliographic source:
Toxicology 328 (2015) 29-39

Materials and methods

Type of study / information:
Transcriptomic data
Test guideline
Qualifier:
no guideline available
GLP compliance:
not specified
Remarks:
Research study without information on GLP

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
Material was purchased from Sigma-Aldrich Catalog number 376663, and described as ester content ≥99 % (mixture of C9 isomers), technical grade

Results and discussion

Any other information on results incl. tables

Authors indicate based on hierarchical clustering analysis there is similar gene expression patterns under the test conditions for DEHP, DINP, clofibrate, and WY-14,643, all known peroxisome proliferation inducing agents in the rat.

Applicant's summary and conclusion

Conclusions:
The authors report a toxicogenomic evaluation of several chemicals including DINP. The results indicate a liver gene expression pattern in rats consistent with that observed with other peroxisome proliferation inducing chemicals.