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EC number: 202-908-4
CAS number: 101-02-0
After administration of TPP at all dosages in both sexes, the group mean
number of micronucleated cells per 1000 polychromatic erythrocytes per
animal was comparable to the concurrent control value and within the
laboratory standard range for negative controls obtained in 18 previous
experiments. The PCE/NCE ratio for the test article at 5000 mg/kg in
both sexes was comparable to that of the negative corn oil control
The mean number of micronucleated cells per 1000 polychromatic
erythrocytes per animal for the concurrent positive control group
(mitomycin C) was significantly higher than the negative control group.
Also, the PCE/NCE for mitomycin C was significantly higher than the
negative control group.
Based on the conditions of this study, it was concluded that the test
article, TPP, was considered to be negative in both sexes for mutagenic
potential and bone marrow toxicity when administered orally.
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