Registration Dossier
Registration Dossier
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EC number: 201-116-6 | CAS number: 78-42-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No OECD guideline or GLP study.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 958
Materials and methods
- Principles of method if other than guideline:
- Other: acute toxicity, oral, rat
- GLP compliance:
- not specified
- Test type:
- other: Acute toxicity: oral
- Limit test:
- no
Test material
- Reference substance name:
- Tris(2-ethylhexyl) phosphate
- EC Number:
- 201-116-6
- EC Name:
- Tris(2-ethylhexyl) phosphate
- Cas Number:
- 78-42-2
- Molecular formula:
- C24H51O4P
- IUPAC Name:
- tris(2-ethylhexyl) phosphate
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: oil (not specified)
- Details on oral exposure:
- no data
- Doses:
- 2,5; 5,0; 10,0 ccm/kg bw.
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 10 other: ccm/kg bw
- Remarks on result:
- other: corresponds to 9260 mg/kg at a density of 0.926 g/cm³
- Mortality:
- no mortalities
- Clinical signs:
- other: diminuated general condition
- Gross pathology:
- no data
- Other findings:
- no data
Any other information on results incl. tables
In an acute oral toxicity study the test substance was administered to white male rats.
The animals showed only a diminuated general condition, but no signs of intoxication or mortalities.
The doses tested were: 2.5; 5.0; 10.0 ccm/kg bw. The LD50 was >10.0 ccm/kg bw (corresponds to 9260 mg/kg at a density of 0.926 g/cm³).
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of this substance to the rat was determined to be >9,260 mg/kg bw.
- Executive summary:
In an acute oral toxicity study the test substance was administered to white male rats. The animals showed only reduced general condition, but no specific signs of intoxication or mortalities. The doses tested were: 2.5; 5.0; 10.0 ccm/kg bw. The LD50 was >10.0 ccm/kg bw (corresponds to 9260 mg/kg at a density of 0.926 g/cm³)
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