Registration Dossier
Registration Dossier
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EC number: 201-116-6 | CAS number: 78-42-2
Neurotoxicity
Administrative data
Description of key information
Conclusion:
No neurotoxic effects were observed in an acute toxicity study in hen and no deviation of cholinesterase activity in red blood cells was measured in a 28 days cat study specifically designed to examine this parameter. Also in the repeated dose inhalation studies in dog and monkey no effects according to neurotoxicity were observed.
Key value for chemical safety assessment
Additional information
In an acute oral neurotoxicity study in hens (the species most relevant for examination of phosphoric acid ester type neurotoxicity), the animals received following doses: 500, 2500 mg/kg bw. and were kept under observation for four weeks. One animal of the high dose group died, the other animals appeared normal and maintained or gained weight. Macroscopic examination revealed no abnormalities; histological there was no evidence of demyelinizing action. No neuropathological changes of brain, spinal cord and sciatic nerve were observed (MacFarland, 1966).
In a 28-day study in cats 1,0 ccm/kg bw test substance was administered daily by gavage. During this treatment period and also in the following observation period no signs of intoxication could be observed. No inhibition of cholinesterase activity in red blood cells was measured. The NOAEL was >1 ccm/kg bw (Kimmerle 1958).
In the already described repeated dose inhalation studies in dog and monkey also no effects related to neurotoxicity were observed (MacFarland, 1966).
Justification for classification or non-classification
Classification: Classification is not required.
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