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EC number: 265-198-5
CAS number: 64742-94-5
A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165°C to 290°C (330°F to 554°F).
The duration of pregnancy was identical in all groups.
No significant effects on litter size. The mean body weight of offspring
of dams exposed to 1000 and 1200 ppm toluene was significantly lower at
birth. The reduction of the offspring mean body weight remained until
postnatal day 7 in the 1200 ppm group. There was a significantly higher
mortality prior to weaning in the 1200 ppm group (7% v. 2.6%).
Incisor eruption and vaginal opening were delayed at 1200 ppm. Vaginal
opening was also delayed at 1000 ppm.
No treatment-related effects.
were no differences in the development of reflexes, rota rod performance
and locomotor activity between the offspring of animals exposed to
toluene and the controls.
were no differences in locomotor activity between the offspring of
animals exposed to toluene and the controls.
No concentration-dependent adverse effects were detected.
toxicity and post-natal development were assessed in groups of >20
pregnant female rats exposed to toluene via inhalation 6 h/day during
gestation (days 9 -21). Exposure concentrations were 0, 300, 600, 1000
or 1200 ppm. A detailed evaluation of physical development of offspring
was conducted and the following tests performed: fore-limb grasp reflex,
righting reflex, cliff-drop aversion reflex, maintenance of balance on a
rotating rod, locomotor activity, learning ability in a discrimination
toluene exposures of 1200 ppm resulted in a reduced body weight gain of
rat dams and offspring had lower body weight at birth and day 7 and a
higher mortality until weaning. Some developmental landmarks (incisor
eruption and vaginal opening) were delayed in this group and are likely
to be secondary to the effect on body weight. At 1000 ppm maternal body
weight gain was low and offspring had low body weight at birth and
delayed vaginal opening. 600 ppm (2261 mg/m3) is the NOAEC for both
maternal toxicity and developmental toxicity.
There were no differences in the development
of reflexes, rota rod performance and locomotor activity that were
attributable to treatment with toluene and no effects were found on
learning ability in the operant conditioning task. There were no
differences in mating, fertility and pregnancy indexes in the
F1-generation. 1200 ppm (4522 mg/m3) is the NOAEC for effects on
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