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EC number: 265-198-5
CAS number: 64742-94-5
A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165°C to 290°C (330°F to 554°F).
non-activated cultures that were cloned exhibited mutant frequencies
which were significantly greater than the mean mutant frequency of the
solvent controls (mutant frequencies 31.0, 3.6 and 2.0 times greater
than controls and respective total growth was 1, 2 and 10%). As API
83-06 has a very steep toxic response curve in this system, minute
differences in dose result in large differences in total growth. The
total growth exhibited by each culture may be more representative of
dose delivered than the concentration of API 83-06 indicated. A
comparison of induced mutant frequency with total growth indicates a
dose-dependent response and the data are judged equivocal.
activated cultures that were cloned exhibited mutant frequencies which
were more than twice the mean mutant frequency of the solvent controls.
Total growth of these cultures was 4 and 7%. A dose-dependent response
was re-tested with S9 activation. The cultures that were cloned were
treated with a range of concentrations which produced 10-91% total
culture exhibited a mutant frequency which was 2.1 times solvent control
mean frequency. However, the duplicate culture for this dose (0.22
µL/mL) did not exhibit a significant increase in mutant frequency. A
dose-dependent response was noted in the treated cultures. The mutagenic
response of API 83-06 in the presence of S9 activation is classed as
“equivocal” since a reproducible positive response was not observed.
conditions of these tests, Heavy catalytic reformed naphtha (petroleum),
API 83-06, produced an equivocal response in the presence and absence of
exogenous metabolic activation.
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