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EC number: 265-198-5
CAS number: 64742-94-5
A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165°C to 290°C (330°F to 554°F).
Repeated dose (6-hour dermal applications)
toxicity of heavy catalytic reformed naphtha (API 83-06) was
investigated in groups of 5 male and 5 female rabbits. The neat test
substance was applied to skin over a period of 28 days (3 times/week,
total of 12 applications) at doses of 0, 200, 1000 or 2000 mg/kg/day.
Animals were observed daily for clinical signs of toxicity and skin
irritation, bodyweight was measured at intervals and at the end of the
study blood samples were analysed for changes in haematology and
clinical chemistry, a selection of organs were weighed and a full range
of tissues examined histopathologically.
The NOAEL for heavy catalytic reformed
naphtha (API 83-06) (CAS 64741-68-0) for systemic toxicity was 2000
mg/kg/day. A NOAEL was not established for local irritant effects - 200
mg/kg was a LOAEL based on slight to moderate irritation based on Draize
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