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EC number: 265-198-5
CAS number: 64742-94-5
A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165°C to 290°C (330°F to 554°F).
the key study, sensitisation potential of dicyclopentadiene 75% was
investigated in female guinea pigs in a modified (9 -induction) Buehler
test, according to OECD guideline 406. Guinea pigs were dermally exposed
to 0.5 mL undiluted dicyclopentadiene 75% for each of 9 induction phases
(Safepharm, 1989e). Scattered mild redness was commonly seen at the
induction sites during the induction phase. Other adverse skin reactions
were fissuring, dry, thickened, straw-coloured skin (possible
hyperkeratinisation), loss of skin suppleness, superficial cracking of
the skin and small superficial scattered scabs. These reactions
sometimes precluded evaluation of erythema. Following challenge with 0.2
mL undiluted dicyclopentadiene 75%, no skin responses were noted in test
or control animals at 24 or 48 hours after challenge. Dicyclopentadiene
75% was therefore considered to be a non-sensitiser to guinea pig skin.
the supporting study (Litton Bionetics, 1976a), 8 guinea pigs were
induced with 10 intracutaneous injections (3/week) of 0.1%
dicyclopentadiene (0.05 – 0.1mL). No skin reactions were observed. Two
weeks after the last dose, the animals were challenged by injection with
0.05mL of 0.1% dicyclopentadiene and skin reactions graded using the
Draize scheme. Mild
erythema was seen 24-48 h after administration of this challenge and
this was evaluated as a negative response.
No relevant information
Migrated from Short description of
Dicyclopentadiene is considered not to be a skin sensitiser.
Non human information
There are no specific animal studies to
assess respiratory sensitisation but a wide range of inhalation studies
in a number of animal species have shown no evidence of respiratory
little information has been reported on the irritation effects of
dicyclopentadiene in humans. However, in a study in volunteers to
determine the human sensory response to dicyclopentadiene vapour and to
determine the odour threshold (Kinkead et al, 1971) there was no
evidence of respiratory sensitisation.
Migrated from Short description of
There are no specific animal studies to assess respiratory
sensitisation but there is no evidence of respiratory sensitisation from
the existing animal and human studies with dicyclopentadiene.
Dicyclopentadiene was shown to be
non-sensitising in a guideline skin sensitisation study in animals and
therefore requires no classification under CLP.
Since there is no evidence for respiratory
sensitisation in a range of inhalation studies in various animal species
or in the limited documented human exposures, dicyclopentadiene is
considered not to warrant classification under CLP.
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