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EC number: 273-227-8
CAS number: 68953-84-4
Dietary exposure to DAPD for 2 generations of rats
resulted in parental toxicity at 120, 400, & 1500 ppm. Polycystic
kidneys were present in F0 & F1 adults, and in F1 & F2 weanlings in all
treatment groups. The renal results for all populations in lowest
exposure group (120 ppm) exhibited only minimal polycystic changes.
Slight increases were seen in relative liver wts in parental F0 & F1
male high dose rats. Reproductive effects included a decreased
gestational index in the F0 generation at the high dose only, and
increased gestational lengths in the F0 (mid & high dose) and F1 (all
doses) deliveries. The number of total & live births per litter on
post-natal day 0 were diminished to a degree in all dose groups of the
F1 & F2 generations with statistical significance seen in the mid and
high dose F1 litters, and high dose F2 litter.
No reproductive toxicity was observed in males due to
chemical exposures. The most pronounced effects in females was delayed
parturition which may have been associated with the increased perinatal
mortality and decreased live births. This finding has been previously
observed for R-59 (N,N'-diphenyl-p-phenylene) in the published
literature. The NOEL for this study is <120 ppm dietary level.
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