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EC number: 273-227-8
CAS number: 68953-84-4
* Micronucleated polychromatic erythrocytes - percentage compared to
DAPD was administered to mice by intraperitoneal injections at doses
that included toxic responses (lethality, behavioural effects, and
decreased PCE/NCE ratio). Erythrocytes were isolated from the femur
marrow at periods up to 72 hr post dosing. These cells were assessed for
evidence of micronuclei induction in PCEs with an increase seen only for
the positive control TEM. DAPD was not found to possess clastogenic
activity in this mouse erythropoietic cell in vivo assay for micronuclei.
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