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Diss Factsheets
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EC number: 206-059-0 | CAS number: 298-14-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure according to national standards, test performed in governmental laboratory
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- only strains TA 97 and TA 102 tested
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Potassium carbonate
- EC Number:
- 209-529-3
- EC Name:
- Potassium carbonate
- Cas Number:
- 584-08-7
- Molecular formula:
- CH2O3.2K
- IUPAC Name:
- dipotassium carbonate
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: Salmonella typhimurium TA97, TA102
- Metabolic activation:
- with and without
- Test concentrations with justification for top dose:
- 0, 100, 500, 1000, 5000, 10000 µg/plate
- Vehicle / solvent:
- Destilled water
Controlsopen allclose all
- Negative solvent / vehicle controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- 9-aminoacridine
- Remarks:
- Migrated to IUCLID6: 50 µg/plate for TA 97 without metabolic activation
- Positive controls:
- yes
- Positive control substance:
- other: 2-Aminoanthracene 5 µg/plate for all strains with metabolic activation
- Positive controls:
- yes
- Positive control substance:
- mitomycin C
- Remarks:
- Migrated to IUCLID6: 0,5 µg/plate for TA 102 without metabolic activation
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in medium; in agar (plate incorporation); preincubation
DURATION
- Preincubation period: 20 minutes
NUMBER OF REPLICATIONS:
- 3 plates for each concentration
The test was performed according to the procedures described by Ames et al. 1975
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: Salmonella typhimurium TA97, TA102
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- other: not reported
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: negative
The test substance Potassium carbonate anhydrous was considered to be negative with and without metabolic activation in this study. - Executive summary:
In a reverse gene mutation assay in bacteria according to the method of Ames et al. (1975), S. typhimurium strains TA 97 and TA 102 of were exposed to Potassium carbonate anhydrous at concentrations of 100, 500, 1000, 5000 and 10 000 µg/plate in the presence and absence of mammalian metabolic activation using the pre-incubation method.
Potassium carbonate anhydrous was tested far beyond the limit concentration of 5000 µg/plate. Cytotoxicity was not reported in this study.
There was no evidence of induced mutant colonies over background in any of the tested S. typhimurium strain up to and including the highest dose tested.
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