1-vinylimidazole

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1953

Report date:

1953

Reference 2

Reference Type:

study report

Title:

Unnamed

Year:

1951

Report date:

1951

Reference 3

Reference Type:

review article or handbook

Title:

High-Performance Fibers to Imidazole and Derivatives

Author:

Elvers B, Hawkins S, Ravenscroft M, Schulz G

Year:

1989

Bibliographic source:

Ullmann's Encyclopedia of Industrial Chemistry, 5th Edition, Vol A13, 1989

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Version / remarks:

prior to OECD test guideline

Principles of method if other than guideline:

BASF-Test: The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401.
Test groups consisting of 5 animals/dose were treated by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

1-vinylimidazole

EC Number:

214-012-0

EC Name:

1-vinylimidazole

Cas Number:

1072-63-5

Molecular formula:

C5H6N2

IUPAC Name:

1-ethenyl-1H-imidazole

Details on test material:

- Name of test material (as cited in study report): N-Vinylimidazol

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

ENVIRONMENTAL CONDITIONS
no data

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 10% solution

Doses:

0.5, 1.0 and 2.0 cm3/kg (ca. 520, 1040 and 2080 mg/kg bw)

No. of animals per sex per dose:

5 animals per dose

Control animals:

no

Details on study design:

- Duration of observation period following administration: 5 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: body weight

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

ca. 1 040 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Original data: 1 cm³/kg

Mortality:

520 mg/kg bw: no animals died
1040 mg/kg bw: 2/5 animals died
2080 mg/kg bw: all animals died within 2-5 days

Clinical signs:

other: No unusual findings were recorded