Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
other: summary of experimental results
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1986
Report date:
1986

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
A short abstract reviewing literature on TBTO reporting the substance as highly incompatible for the eyes of rabbits at 0.15-2% in an aqueous formulation.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Bis(tributyltin) oxide
EC Number:
200-268-0
EC Name:
Bis(tributyltin) oxide
Cas Number:
56-35-9
Molecular formula:
C24H54OSn2
IUPAC Name:
tributyl[(tributylstannyl)oxy]stannane
Details on test material:
Reported as Tributyltin oxide (TBTO) , with the synonyms bis (tri-n-butyltin) oxide or hexa-n-butyldistannoxane

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
water
Controls:
not specified
Amount / concentration applied:
0.15-2.0%
Duration of treatment / exposure:
No information
Observation period (in vivo):
No information
Number of animals or in vitro replicates:
No information

Results and discussion

In vivo

Results
Remarks on result:
other: Test material was reported to be highly incompatable in the eyes.
Irritant / corrosive response data:
Test material was reported to be highly incompatable in the eyes. in consideration of these findings as well as those of the results on skin tolerance, studies on the effects of tributyltin compounds on the rabbit eye were not performed on ethical grounds.

Applicant's summary and conclusion

Conclusions:
In a review of the literature, aqueous solutions of the test material were found to be highly incompatable with the eyes of rabbits. Further testing was not performed on ethical grounds.
Executive summary:

In a review of the literature, aqueous solutions of the test material were found to be highly incompatable with the eyes of rabbits. Further testing was not performed on ethical grounds.