Reaction mass of ethyl (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoate and ethyl (2E,4Z,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoate

Guidance on Safe Use

First-aid measures

Description of first aid measures
General information: Immediately remove any clothing soiled by the product.
After inhalation: In case of unconsciousness place patient stably in side position for transportation.
After skin contact: Immediately wash with water and soap and rinse thoroughly.
After eye contact: Rinse opened eye for several minutes under running water. If symptoms persist, consult a doctor.
After swallowing:
Drink plenty of water and provide fresh air. Call for a doctor immediately.

Most important symptoms and effects, both acute and delayed Contact with dust may cause irritation of mucous membranes.
Hypervitaminosis-A-syndrome by intake in therapeutic doses: Dry lips, headache, effects on skin, itching.
Burning of eyes, mucous membranes and skin.
Coughing, headache, indisposition, shortness of breath.
Information for doctor: Pregnant and brestfeeding women should not be exposed to this material.
Skin: After contact with this substance reddening and irritation of skin may occur.
Irritation
Eyes: Dust may irritate eyes mechanically.
Respiratory tract: After breathing of dust possible rritation of nose, respiratory tract, lungs: Cough, shortness of breath.
Hazards and systemic effects: Strong irritating effect after breathing of dust and contact with eyes.
Possible reproductive effects.
May cause harm to the unborn child.
Possible routes of intake: Intake by swallowing or inhalation of dust.
Target organs: Skin, eyes, mucous membranes.
Respiratory tract
Chronic effects: Teratogenic effects.

Indication of any immediate medical
attention and special treatment needed No further relevant information available.

Fire-fighting measures

Extinguishing media
Suitable extinguishing agents: CO₂, powder or water spray. Fight larger fires with water spray or alcohol resistant foam.
For safety reasons unsuitable extinguishing agents: No restriction in large fires.

Special hazards arising from the substance or mixture: In case of fire, the following can be released:
Carbon monoxide (CO)
Very high danger of dust explosions.

Advice for firefighters
Protective equipment: Wear self-contained respiratory protective device.
Chemical resistant protective suit.
Under the protective suit a fire protective suit according to EN 469 should be applied.
Use chemical protective suit and self contained breathing apparatus while undressing contaminated co-workers or handling contaminated equipment.

Additional information: Dispose of fire debris and contaminated fire fighting water in accordance with official regulations.
Collect contaminated fire fighting water separately. It must not enter the sewage system.

Accidental release measures

Personal precautions, protective equipment and emergency procedures
Wear protective clothing.
Avoid contact with eyes and skin and clothes
Do not breathe dust.
Access only for trained personnel with personal protective equipment.
Use respiratory protective device against the effects of fumes/dust/aerosol.
Avoid spillage of product into the environment.
Avoid formation of dust.
Implementation of further measures based on existing emergency plans.

Environmental precautions: Keep contaminated washing water and dispose of appropriately.
Inform respective authorities in case of seepage into water course or sewage system.
Do not allow undiluted product or large quantities of it to reach ground water, water course or sewage system.

Methods and material for containment and cleaning up: Pick up mechanically. If formation of dust cannot be avoided use respiratory filter device.
Ensure adequate ventilation.
Possible formation of explosive dust/air mixtures.
Dispose contaminated material as waste accordingly.

Discharge into waste water channels and biological treatment plants only after clearance with the operating company and in accordance with local Authority approval.

Handling and storage

Precautions for safe handling: Inert gas blanketing required.
Empty containers must not be used for other products.
Contaminated protective equipment should be cleaned before taking it off.
Any unavoidable deposit of dust must be completely removed.
Ensure good ventilation/exhaustion at the workplace.
Fill only in dedicated and assigned containers.
Keep containers tightly sealed.
Information about fire - and explosion protection: Very high danger of dust explosions.

Conditions for safe storage, including any incompatibilities:
Storage
Requirements to be met by storerooms and
receptacles: Storage under inert gas.
Store in a dry location, keep away from humidity.
Store in a cool location.
Store protected from sunlight.
Suitable materials: Precious steel
Aluminium
Suitable material for containers: Aluminium
Stainless steel
Corrosion of metals: No corroding action on metals (expert statement).
Information about storage in one common
storage facility: Do not store together with alkalis (caustic solutions).
Store away from oxidising agents.
Further information about storage
conditions: Avoid contact with air / oxygen.
Protect from exposure to the light.
Store under inert gas.
Acceptable storage time: 48 Mo.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

3077

Shipping information

Proper shipping name and description:

ENVIRONMENTAL L Y HAZ ARDOUS
SUBSTANCE, SOLID, N.O.S. (Etretinate)

Chemical name:

Reaction mass of 13-cis-Etretinate and 13-trans-Etretinate

Class or division:

Class 9: Miscellaneous dangerous substances and articles, including environmentally hazardous substances

Packing group:

Packing group III: Substances presenting low danger

Labels:

9

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

3077

Shipping information

Proper shipping name and description:

ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Etretinate)

Chemical name:

Reaction mass of 13-cis-Etretinate and 13-trans-Etretinate

Class or division:

Class 9: Miscellaneous dangerous substances and articles, including environmentally hazardous substances

Packing group:

Packing group III: Substances presenting low danger

Labels:

9

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

3077

Shipping information

Proper shipping name and description:

ENVIRONMENTALLY HAZARDOUS SUBSTANCE,
SOLID, N.O.S. (Etretinate), MARINE POLLUTANT

Chemical name:

Reaction mass of 13-cis-Etretinate and 13-trans-Etretinate

Class or division:

Class 9: Miscellaneous dangerous substances and articles, including environmentally hazardous substances

Packing group:

Packing group III: Substances presenting low danger

Labels:

9

Marine pollutant

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

3077

Shipping information

Proper shipping name and description:

ENVIRONMENTALLY HAZARDOUS SUBSTANCE,
SOLID, N.O.S. (Etretinate)

Chemical name:

Reaction mass of 13-cis-Etretinate and 13-trans-Etretinate

Class or division:

Class 9: Miscellaneous dangerous substances and articles, including environmentally hazardous substances

Packing group:

Packing group III: Substances presenting low danger

Labels:

9

Remarks

SpecialProvisions

Exposure controls / personal protection

Additional information about design of technical facilities: Take care of sufficient ventilation. Avoid formation of dust.
Waste gases should be led into the atmosphere only via appropriate separators, scrubbers or incinerators.

Control parameters
Ingredients with limit values that require monitoring at the workplace: Not required.
DNEL/PNEC-values: This product is not subject to registration under REACH. Therefore the determination of DNEL/PNEC-values is not mandatory.
Recommendation of producer: IOEL: 0.004 mg/m³ (women)
IOEL: 0.04 mg/m³ (men)
OEL (DSM-internal): 4 μg/m³

Exposure controls:
Personal protective equipment
General protective and hygienic measures: Contaminated protective suit shall be cleaned before taking it off.
Keep away from foodstuffs, beverages and feed.
Immediately remove all soiled and contaminated clothing
Wash hands before breaks and at the end of work.
Store protective clothing separately.
Avoid contact with the skin.
Avoid contact with the eyes and skin.
Inhalation of dust/vapours or contact with skin should be strictly avoided with pregnant women.
Respiratory protection: Particle fi lter. The fi lter grade (P1 - P3) has to be established depending on work-place related limit values
and the actual exposition.
Protection of hands:
Protective gloves.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation.
For the permanent contact gloves made of the following materials are suitable: The following materials are known from experience to be suitable for protection against undissolved solids: rubber.
Check for tightness before use.
Replace damaged gloves.
Eye protection:
Safety glasses
Body protection: Use protective suit with self-contained breathing apparatus.
Protection against thermal hazards: No specific measures required.
Limitation and supervision of exposure into the environment: Avoid spillage of product into the environment.
If possible use this material only in closed systems and devices. In case of open plant systems (sampling devices, filling and discharging, cleansing works etc.) use local exhaust and collecting trays. Follow emission limit values. Measures in case of unwanted emissions should be established.

Risk management measures:
General protective and hygienic measures have to be observed.
Handling and use of this material/formulation only under controlled conditions in closed systems.
Employees who use this material/formulation must be trained and demonstrably instructed about possible risks for man and environment.
Measures for prevention of hazards in case of unwanted leakage shall be implemented.

Stability and reactivity

Reactivity

Chemical stability
Thermal decomposition / conditions to be
avoided: High risk of dust explosion!
Sensitive to:
Air: Sensitive to air.
Inert gas blanketing required.
Light: Sensitive to light.
Protect from light..
Temperature: Protect from heat.

Possibility of hazardous reactions: Very high danger of dust explosions.

Conditions to avoid: Heating

Incompatible materials: Strong oxidizing agents.
Oxygen
Bases

Hazardous decomposition products: Carbon monoxide
Carbon monoxide and carbon dioxide
Additional information: Sensitive to air.

Disposal considerations

Waste treatment methods
Recommendation:
Must not be disposed together with household garbage. Do not allow product to reach sewage system.
Must be specially treated adhering to official regulations.

Uncleaned packaging
Recommendation: Empty contaminated packagings thoroughly. They may be recycled after thorough and proper cleaning.
Contaminated containers or containers with residual amounts must be treated as hazardous wastes.
Appropriate disposal: Empty container completely.
Storage in a safe place after emptying.
Biological waste water treatment: Discharge into waste water channels and biological treatment plants only after clearence with the operating company and in accordance with local Authority approval.