Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information

Phenethylammonium salt of fosfomycin is an organic salt, freely soluble in water, which dissociates into fosfomycin ((3-methyloxiran-2-yl) phosphonic acid)) and phenethylammonium ions within the environmentally relevant pH range (5-8). Experimental Log Koc for phenethylammonium is 4.54. Fosfomyc in anion has weak UV absorption and was not detectable at the selected wavelenght in the absorption study, then its Koc has been estimated by KOCWIN v2.00 (US EPA): calculated values of Log Koc for non-ionized fosfomycin are 0.09 (estimate from Log Kow) and 0.07 (estimate from MCI); Koc value for fosfomycin anion is not expected to be significantly different from its non-ionized form.

High mobility in soil is therefore expected for the fosfomycin anion, while pour mobility is expected for phenethylammonium.