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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
not specified
Test type:
traditional method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: granular
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Lot No. 812-141

Test animals

Species:
rat
Strain:
other: Spartan albino rats
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
whole body
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: dynamic air flow chamber
- Exposure chamber volume:
- Method of holding animals in test chamber:
- Source and rate of air:
- Method of conditioning air:
- System of generating particulates/aerosols:
- Method of particle size determination:
- Treatment of exhaust air:
- Temperature, humidity, pressure in air chamber:

TEST ATMOSPHERE
- Brief description of analytical method used:
- Samples taken from breathing zone: yes/no

VEHICLE
- Composition of vehicle (if applicable):
- Concentration of test material in vehicle (if applicable):
- Justification of choice of vehicle:
- Lot/batch no. (if required):
- Purity:

TEST ATMOSPHERE (if not tabulated)
- Particle size distribution:
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.):

CLASS METHOD (if applicable)
- Rationale for the selection of the starting concentration:
Duration of exposure:
4 h
Concentrations:
50 mg/l
No. of animals per sex per dose:
5
Details on study design:
Acute toxicity was evaluated in Spartan albino rats (5 rats/sex), receiving whole-body exposure to micronized tribromophenol at a concentration of 50 mg/l, for 4 hours, in a dynamic air flow chamber.

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 50 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Mortality:
The treatment had no adverse effects with respect to mortality rate.
Clinical signs:
other: During the exposure period, rats exhibited decreased motor activity, eye squint, slight dyspnea, erythema and ocular porphyrin discharge. At 24 hrs, rats exhibited diarrhea, ocularporphyrin discharge, and slight dyspnea. During the 14-day observation peri
Body weight:
The treatment had no adverse effects with respect to body weight gain.
Gross pathology:
A necropsy of all rats following the 14 day observation period did notreveal any compound related findings.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In accordance with the results obtained, the acute inhalation toxicity of TBP would be greater than 50 mg/L.