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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Neurotoxicity

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Administrative data

Description of key information

Available data for this endpoint was provided, however Lyubimov et al. (1998) was not considered of a high enough reliability to fulfil the data requirement as a stand alone study.

Key value for chemical safety assessment

Additional information

Reference: Lyubimov, A., Babin, V.V. and Kartashov, A.I. (1998)

Reliability: 3

Results: The results from this study should be considered qualitative because the stated dose was not analytically confirmed, and is increased by an unknown amount based on grooming behavior during the continuous 21 day gestational exposure.Therefore, the conclusions are also qualitative despite the NOELs and LOELs stated by the study. Although the exact dose is unknown, embryolethality and fetolethality are demonstrated at doses that are not apparently maternally toxic. The toxic parameters included pre-implantation and post-implantation loss, skeletal abnormalities, and greater postnatal mortality.

 

Endpoint

Generation (if applicable)

Sex

Effect level

Based on

Basis for effect level / Remarks

LOEL

maternal

female

1 mg/m³ air (nominal)

labile/free

Not necessarily an adverse effect; decrease in nose-poking behavior in an open field. This dose is the nominal air concentration but does not take into account the oral exposure from grooming after whole-body exposure.

LOEC

offspring

male

> 0.3 mg/m³ air (nominal)

labile/free

The stated effect is not necessarily adverse, and the dose is inaccurate because oral exposure from grooming during continuous dam exposure throughout gestation is not taken into account. 30 and 60 day old male pups exposed in utero had decreased grooming behavior (labelled emotionality by authors).

LOEC

offspring

female

> 0.03 mg/m³ air (nominal)

labile/free

The stated effect is not necessarily adverse, and the dose is inaccurate because oral exposure from grooming during continuous dam exposure throughout gestation is not taken into account. 60 day old females showed decreased grooming behavior (author labels this behavior emotionality).

LOAEC

offspring

male/female

> 1 mg/m³ air (nominal)

labile/free

The dose is inaccurate because oral exposure from grooming during continuous dam exposure throughout gestation is not taken into account. At postnatal day 60, skin pain threshold was significantly increased, leading the authors to conclude that the test compound disrupts the central nervous system.

 

Justification for classification or non-classification

As no reliable data were available from which accurate conclusions could be draw concerning the neurotoxic potential of 2,4,6 -tribromophenol ; no classification can be justifiably assigned.