Registration Dossier
Registration Dossier
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EC number: 614-478-9 | CAS number: 684269-94-1
Toxicity to reproduction
Administrative data
- Endpoint:
- fertility, other
- Remarks:
- based on test type (migrated information)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study has been performed on th structuraly analogue. Study presented to US Food and Drug Administration. No details available.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Materials and methods
- Principles of method if other than guideline:
- details not available
Test material
- Reference substance name:
- (S)-methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate hydrogen sulfate
- EC Number:
- 601-679-1
- Cas Number:
- 120202-66-6
- Molecular formula:
- C16 H16 Cl N O2 S . H2 O4 S
- IUPAC Name:
- (S)-methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate hydrogen sulfate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- not available
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
Results and discussion
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Clopidogrel was found to have no effect on fertility of male and female rats at oral doses up to 400 mg/kg per day.
- Executive summary:
Clopidogrel was found to have no effect on fertility of male and female rats at oral doses up to 400 mg/kg per day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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