Registration Dossier
Registration Dossier
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EC number: 423-710-6 | CAS number: 113170-55-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EEC-Directive B.6 Maximization test
- GLP compliance:
- yes
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- not specified
Test material
- Reference substance name:
- -
- EC Number:
- 423-710-6
- EC Name:
- -
- Cas Number:
- 113170-55-1
- Molecular formula:
- C12H12Mg3O18P2
- IUPAC Name:
- trimagnesium(2+) bis((2R)-2-[(1S)-1,2-dihydroxyethyl]-5-oxo-4-(phosphonatooxy)-2,5-dihydrofuran-3-olate)
- Test material form:
- solid: particulate/powder
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
Study design: in vivo (non-LLNA)
Induction
- Concentration / amount:
- Concentration of test material and vehicle used at induction:
Intradermal and epidermal induction: 25% in distilled water
Concentration of test material and vehicle used for each challenge:
First and second challenge:
50, 25, 10 and 0% in distilled water
Challenge
- Concentration / amount:
- Concentration of test material and vehicle used at induction:
Intradermal and epidermal induction: 25% in distilled water
Concentration of test material and vehicle used for each challenge:
First and second challenge:
50, 25, 10 and 0% in distilled water
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Group:
- negative control
- Remarks on result:
- other: not specified
- Group:
- test chemical
- Remarks on result:
- other: not specified
- Group:
- positive control
- Remarks on result:
- other: not specified
Any other information on results incl. tables
Signs of irritation during induction: After the intradermal induction no abnormalities were seen at the treated areas.
After the epidermal induction slight to well defined erythema was observed in 7/10 experimental animals. The control animals showed no erythema.
In 2 experimental and 1 control animal very small scabs were observed.
Evidence of sensitisation of each challenge concentration: The effects seen at the 25% concentration in the experimental and control animals was considered to be induced by pulling out the hairs while removing the test substance after exposure and not by a allergic reaction.
Therefore, the results lead to a sensitization rate of 0%.
Other observations: no findings
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
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