Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
August 6th - August 14th 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
not specified
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
(2-fluoro-3-methoxyphenyl)boronic acid
EC Number:
609-099-0
Cas Number:
352303-67-4
Molecular formula:
FC6H3(OCH3)B(OH)2
IUPAC Name:
(2-fluoro-3-methoxyphenyl)boronic acid
Test material form:
solid: particulate/powder
Specific details on test material used for the study:
Purity: 100.2%
Batch No.: 18051400
Expiration date: March 14, 2019
Physical status: Off-white solid

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficientopen allclose all
Key result
Type:
log Pow
Partition coefficient:
1.14
Remarks on result:
other: Temp and pH not stated (column temp 30 C)
Key result
Type:
Pow
Partition coefficient:
13.8
Remarks on result:
other: Temp and pH not stated (column temp 30 C)
Details on results:
Temp and pH not stated (column temp 30 C)

Applicant's summary and conclusion

Conclusions:
The partition coefficient (n-octanol/water) of FMPBA was determined compatible with the Principles of OECD guidelines for testing chemicals No. 117 'Partition Coefficient (m-octanol/water), HIgh Performance Liquid Chromatography (HPLC) Method'. Based on the test results the Pow of FMPBA was 13.8, lgPow was 1.14.