Registration Dossier
Registration Dossier
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EC number: 279-075-9 | CAS number: 79135-28-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no guideline followed; however, the study meets generally accepted scientific principles and it is acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
- Principles of method if other than guideline:
- Test method not specified: acute dermal toxicity study in male rats by 4-h exposure to the substance.
- GLP compliance:
- no
Test material
- Reference substance name:
- Acid Brown 303
- IUPAC Name:
- Acid Brown 303
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male
Administration / exposure
- Details on dermal exposure:
- Use of a gauze pads fixed on depilated dorsal skin of rats.
- Duration of exposure:
- 4 h
- Doses:
- 5000 mg/kg bw.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified within the CLP Regulation (EC 1272/2008)
- Conclusions:
- LD50 > 5000 mg/kg bw.
- Executive summary:
Acute dermal toxicity of test substance was assessed in male rats. Test substance was applied on depilated dorsal skin of rats using gauze pads at dose of 5000 mg/kg bw.
LD50 was determined to be > 5000 mg/kg bw.
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