trans-2-(4-Bromo-3-fluorophenyl)-5-butyl-[1,3]dioxane

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2018-11-02 to 2019-01-28

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

GLP compliance:

no

Type of method:

effusion method: Knudsen cell

Temp.:

20 °C

Vapour pressure:

0.001 Pa

Key result

Temp.:

25 °C

Vapour pressure:

0.001 Pa

Temp.:

50 °C

Vapour pressure:

0.034 Pa

The vapour pressure was measured in the temperature range of 15 °C to 120 °C. After the measurement a mass loss of 100 % (w/w) was determined. At 100 °C the test cell was already empty. Therefore, only measurements below 100 °C were used for further evaluation.

Table 1: Measured vapour pressures and corresponding temperatures

Temperature / °C	Vapour pressure / hPa
15	n.e.
20	n.e.
25	1.4E-5
30	3.4E-5
40	9.6E-5
50	3.0E-4
60	1.1E-3
70	3.3E-3
80	8.9E-3
90	2.3E-2

n.e.: not evaluable

The values for 20, 25 and 50 °C were calculated, using the Antoine constants A, B and C.

Table 2: Antoine parameters and extrapolated vapour pressures

T / °C	Log (p/hPa) = A + B / (C + T [°C])	p / hPa	p / Pa
20	A = 13.00439	6.9E-6	6.9E-4
25	B = -5324.83	1.4E-5	1.4E-3
50	C = 273.15	3.4E-4	3.4E-2

 

Conclusions:

The vapour pressure of the test item was determined to be 6.9E-4 Pa at 20 °C, 1.4E-3 Pa at 25 °C and 3.4E-2 Pa at 50 °C, respectively.

Executive summary:

A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item using the effusion method: Knudsen cell. The vapour pressure of the test item was determined at temperatures between 15 and 120 °C. After the measurement a mass loss of 100 % (w/w) was determined. At 100 °C the test cell was already empty. Therefore, only measurements below 100 °C were used for further evaluation. Using the Antoine equation, the constants A and B were determined and the vapour pressure of the test item at 20, 25 and 50 °C was extrapolated from the experimental vapour pressure. The vapour pressure was calculated to be 6.9E-4 Pa at 20 °C, 1.4E-3 Pa at 25 °C and 3.4E-2 Pa at 50 °C, respectively.

Description of key information

The vapour pressure of the test item was determined to be 6.9E-4 Pa at 20 °C, 1.4E-3 Pa at 25 °C and 3.4E-2 Pa at 50 °C, respectively.

Key value for chemical safety assessment

Vapour pressure:

0.001 Pa

at the temperature of:

25 °C

Additional information

A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item using the effusion method: Knudsen cell (reference 4.6-1). The vapour pressure of the test item was determined at temperatures between 15 and 120 °C. After the measurement a mass loss of 100 % (w/w) was determined. At 100 °C the test cell was already empty. Therefore, only measurements below 100 °C were used for further evaluation. Using the Antoine equation, the constants A and B were determined and the vapour pressure of the test item at 20, 25 and 50 °C was extrapolated from the experimental vapour pressure. The vapour pressure was calculated to be 6.9E-4 Pa at 20 °C, 1.4E-3 Pa at 25 °C and 3.4E-2 Pa at 50 °C, respectively.