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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2018-11-02 to 2019-01-28
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
no
Type of method:
effusion method: Knudsen cell
Temp.:
20 °C
Vapour pressure:
0.001 Pa
Key result
Temp.:
25 °C
Vapour pressure:
0.001 Pa
Temp.:
50 °C
Vapour pressure:
0.034 Pa

The vapour pressure was measured in the temperature range of 15 °C to 120 °C. After the measurement a mass loss of 100 % (w/w) was determined. At 100 °C the test cell was already empty. Therefore, only measurements below 100 °C were used for further evaluation.

Table 1: Measured vapour pressures and corresponding temperatures

Temperature / °C

Vapour pressure / hPa

15

n.e.

20

n.e.

25

1.4E-5

30

3.4E-5

40

9.6E-5

50

3.0E-4

60

1.1E-3

70

3.3E-3

80

8.9E-3

90

2.3E-2

n.e.: not evaluable

The values for 20, 25 and 50 °C were calculated, using the Antoine constants A, B and C.

Table 2: Antoine parameters and extrapolated vapour pressures

T / °C

Log (p/hPa) = A + B / (C + T [°C])

p / hPa

p / Pa

20

A = 13.00439

6.9E-6

6.9E-4

25

B = -5324.83

1.4E-5

1.4E-3

50

C = 273.15

3.4E-4

3.4E-2

 

Conclusions:
The vapour pressure of the test item was determined to be 6.9E-4 Pa at 20 °C, 1.4E-3 Pa at 25 °C and 3.4E-2 Pa at 50 °C, respectively.
Executive summary:

A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item using the effusion method: Knudsen cell. The vapour pressure of the test item was determined at temperatures between 15 and 120 °C. After the measurement a mass loss of 100 % (w/w) was determined. At 100 °C the test cell was already empty. Therefore, only measurements below 100 °C were used for further evaluation. Using the Antoine equation, the constants A and B were determined and the vapour pressure of the test item at 20, 25 and 50 °C was extrapolated from the experimental vapour pressure. The vapour pressure was calculated to be 6.9E-4 Pa at 20 °C, 1.4E-3 Pa at 25 °C and 3.4E-2 Pa at 50 °C, respectively.

Description of key information

The vapour pressure of the test item was determined to be 6.9E-4 Pa at 20 °C, 1.4E-3 Pa at 25 °C and 3.4E-2 Pa at 50 °C, respectively.

Key value for chemical safety assessment

Vapour pressure:
0.001 Pa
at the temperature of:
25 °C

Additional information

A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item using the effusion method: Knudsen cell (reference 4.6-1). The vapour pressure of the test item was determined at temperatures between 15 and 120 °C. After the measurement a mass loss of 100 % (w/w) was determined. At 100 °C the test cell was already empty. Therefore, only measurements below 100 °C were used for further evaluation. Using the Antoine equation, the constants A and B were determined and the vapour pressure of the test item at 20, 25 and 50 °C was extrapolated from the experimental vapour pressure. The vapour pressure was calculated to be 6.9E-4 Pa at 20 °C, 1.4E-3 Pa at 25 °C and 3.4E-2 Pa at 50 °C, respectively.