Registration Dossier
Registration Dossier
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EC number: 701-276-1 | CAS number: -
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No long-term fish toxicity tests are available for the test substance. It appears appropriate to waive this study.
Key value for chemical safety assessment
Additional information
The test substances of the methylenediphenyl isocyanate (MDI) category react quickly with water and hence could rapidly be hydrolysed in aqueous solution (T1/2 = 20h). However, MDI is hydrophobic and poorly soluble in water and thus the heterogeneous reaction with water or soil is less rapid. The major product of such a reaction is a solid, insoluble polyurea. Under conditions typical of many types of environmental contact, i. e. with relatively poor dispersion of the denser isocyanate, the interfacial reaction leads to the formation of a solid crust encasing partially or unreacted material. This crust restricts ingress of water and egress of amine, and hence slows and modifies hydrolysis.
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