(3S)-3,7-Dimethyl-1-octanol

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2000

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

2000

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

See read-across justification attached in section 13.2

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

EU Method C.2 (Acute Toxicity for Daphnia)

GLP compliance:

yes

Analytical monitoring:

yes

Test organisms (species):

Daphnia magna

Details on test organisms:

- Origin: Strain of Bundesgesundheitsamt Berlin
- Maintenance and acclimatisation:
- A population of parthenogenetic females of synchronized age structure is maintained under constant temperature conditions (20 +/- 1°C) at a
16:8 hour light-dark photoperiod (illumination: < 1000 lux).
- M4 medium is partly renewed once a week
- Daphnia are exclusively fed with unicellular green algae ad libitum
- The neonates are separated from their parent Daphnia by filtration prior to the acute test

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Test temperature:

20.1 °C

pH:

7.7

Dissolved oxygen:

8.4 mg/L

Nominal and measured concentrations:

Test concentrations (mg/L): 3.4, 6.9, 13.8, 27.5 and 55 (nominal)

Details on test conditions:

- Test vessels: 50 ml glass beakers holding 10 meonates in 20 ml of test medium
- Experimental design:
- 5 test concentrations plus 1 control
- 10 neonates per vessel, 2 replicates per concentration / control
- no feeding during the exposure period
- Photoperiod: 16 h light : 8 h dark
- Aeration: none

Reference substance (positive control):

not specified

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

3.6 mg/L

Nominal / measured:

meas. (geom. mean)

Conc. based on:

test mat.

Basis for effect:

mobility

Details on results:

48 h EC0 1.3 mg/L (measured)
48 h EC100 9.8 mg/L (measured)

Results with reference substance (positive control):

not specified

Validity criteria fulfilled:

not specified

Conclusions:

According to the study carried out on the mobility of Daphnids, the EC50 of the test substance was found to be 3.6 mg/L (based on the measured geometrical mean).

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2000

Report date:

2000

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method C.2 (Acute Toxicity for Daphnia)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

3,7-dimethyloctan-1-ol

EC Number:

203-374-5

EC Name:

3,7-dimethyloctan-1-ol

Cas Number:

106-21-8

Molecular formula:

C10H22O

IUPAC Name:

3,7-dimethyloctan-1-ol

Sampling and analysis

Analytical monitoring:

yes

Test organisms

Test organisms (species):

Daphnia magna

Details on test organisms:

- Origin: Strain of Bundesgesundheitsamt Berlin
- Maintenance and acclimatisation:
- A population of parthenogenetic females of synchronized age structure is maintained under constant temperature conditions (20 +/- 1°C) at a
16:8 hour light-dark photoperiod (illumination: < 1000 lux).
- M4 medium is partly renewed once a week
- Daphnia are exclusively fed with unicellular green algae ad libitum
- The neonates are separated from their parent Daphnia by filtration prior to the acute test

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Test conditions

Test temperature:

20.1 °C

pH:

7.7

Dissolved oxygen:

8.4 mg/L

Nominal and measured concentrations:

Test concentrations (mg/L): 3.4, 6.9, 13.8, 27.5 and 55 (nominal)

Details on test conditions:

- Test vessels: 50 ml glass beakers holding 10 meonates in 20 ml of test medium
- Experimental design:
- 5 test concentrations plus 1 control
- 10 neonates per vessel, 2 replicates per concentration / control
- no feeding during the exposure period
- Photoperiod: 16 h light : 8 h dark
- Aeration: none

Reference substance (positive control):

not specified

Results and discussion

Effect concentrations

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

3.6 mg/L

Nominal / measured:

meas. (geom. mean)

Conc. based on:

test mat.

Basis for effect:

mobility

Details on results:

48 h EC0 1.3 mg/L (measured)
48 h EC100 9.8 mg/L (measured)

Results with reference substance (positive control):

not specified

Applicant's summary and conclusion

Validity criteria fulfilled:

not specified

Conclusions:

According to the study carried out on the mobility of Daphnids, the EC50 of the test substance was found to be 3.6 mg/L (based on the measured geometrical mean).