Registration Dossier
Registration Dossier
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EC number: 254-159-8 | CAS number: 38861-78-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- secondary source
- Title:
- IUCLID dataset for 38861-78-8
- Author:
- European Commission - European Chemicals Bureau
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1981
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1-[4-(2-methylpropyl)phenyl]ethan-1-one
- EC Number:
- 254-159-8
- EC Name:
- 1-[4-(2-methylpropyl)phenyl]ethan-1-one
- Cas Number:
- 38861-78-8
- Molecular formula:
- C12H16O
- IUPAC Name:
- 1-[4-(2-methylpropyl)phenyl]ethan-1-one
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: intact
- Vehicle:
- not specified
- Amount / concentration applied:
- A single dose of 0.5 ml were given
- Duration of treatment / exposure:
- One application for four hours
- Observation period:
- Seven days
- Number of animals:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- other: not specified
- Basis:
- mean
- Time point:
- 7 d
- Reversibility:
- fully reversible within: 7 d
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Animals elicited slight to well-defined (one animal only) dermal reactions. All reactions had resolved by day 7.
Applicant's summary and conclusion
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