Registration Dossier
Registration Dossier
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EC number: 236-031-3 | CAS number: 13106-76-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from NTRL reports
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Initial submission: The acute of toxicity certain compounds of molybdenum report to the International Molybdenum Association with attachments and cover letter dated 062891
- Author:
- International Molybdenum association
- Year:
- 1 991
- Bibliographic source:
- NTRL submission report -OTS0000811, last updated 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- The dermal irritation potential of Ammonium molybdate was assessed in rabbits according to OECD 404 Guidelines
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ammonium molybdate(VI)
- EC Number:
- 236-031-3
- EC Name:
- Ammonium molybdate(VI)
- Cas Number:
- 13106-76-8
- Molecular formula:
- H4N.1/2MoO4
- IUPAC Name:
- ammonium molybdate(VI)
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): ammonium molybdate(VI)
- Molecular formula: MoO4.2H4N
- Molecular weight: 196.0132 g/mol
- Smiles notation: [Mo](=O)(=O)([O-])[O-].[NH4+].[NH4+]
- InChl: 1S/Mo.2H3N.4O/h;2*1H3;;;;/q;;;;;2*-1/p+2
- Substance type: Inorganic
- Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): ammonium molybdate(VI)
- Molecular formula: MoO4.2H4N
- Molecular weight: 196.0132 g/mol
- Smiles notation: [Mo](=O)(=O)([O-])[O-].[NH4+].[NH4+]
- InChl: 1S/Mo.2H3N.4O/h;2*1H3;;;;/q;;;;;2*-1/p+2
- Substance type: Inorganic
- Physical state: Solid
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
-Sex: Female
- Source: A. Smith, Warlingham. Surrey
- Age at study initiation: 9 to 12 weeks of age
- Weight at study initiation: 2.2 to 2.7 kg
- Fasting period before study:
- Housing: The rabbits were individually housed in metal cages with perforated floors in Building
- Diet (e.g. ad libitum): SDS Standard Rabbit Diet
- Water (e.g. ad libitum):Tap water
- Acclimation period: The rabbits selected for the study were all acclimated to the laboratory environment
ENVIRONMENTAL CONDITIONS
- Temperature (°C):19 deg C
- Humidity (%):Relative humidity:30-70%
- Air changes (per hr): 19 air changes per hour
- Photoperiod (hrs dark / hrs light): 12 hours of artificial light in each 24 hour period.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 gm
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- Day 1(approximately 30 minutes after removal of the patches) and on Days 2, 3 and 4.
- Number of animals:
- 6 female rabbits
- Details on study design:
- TEST SITE
- Area of exposure: dorso-lumbar region
- % coverage: 10 cm square patch
- Type of wrap if used: Elastoplast
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: At the end of the exposure period, the semi-occlusive dressing and gauze pad were removed and the treatment site was washed using water to remove any residual test substance.
SCORING SYSTEM:
Grading and scoring of the dermal reactions were performed using the prescribed numerical scoring system.
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No dermal irritation observed
Any other information on results incl. tables
Table: Dermal reactions elicited by Ammonium Molybdate
Rabbit number |
Sex
|
E =Erythema o =Oedema |
Day |
|||
1* |
2 |
3 |
4 |
|||
1 |
female |
E |
0 |
0 |
0 |
0 |
O |
0 |
0 |
0 |
0 |
||
2 |
Female |
E |
0 |
0 |
0 |
0 |
O |
0 |
0 |
0 |
0 |
||
3 |
Female |
E |
0 |
0 |
0 |
0 |
O |
0 |
0 |
0 |
0 |
||
4 |
Female |
E |
0 |
0 |
0 |
0 |
O |
0 |
0 |
0 |
0 |
||
5 |
Female |
E |
0 |
0 |
0 |
0 |
O |
0 |
0 |
0 |
0 |
||
6 |
Female |
E |
0 |
0 |
0 |
0 |
O |
0 |
0 |
0 |
0 |
||
*-Approximately 30 minutes after removal of dressing
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- A single semi-occlusive application of Ammonium Molybdate to intact rabbit skin for four hours elicited no dermal irritation.
The overall irritation index after 4 days of observation was 0.0.
Hence, Ammonium molybdate can be considered not irritating to skin. - Executive summary:
A study was conducted to assess the irritation potential of ammonium molybdate. The study was conducted as per OECD 404 Guidelines.
0.5 gm of test chemical was applied to the dorso-lumbar region exposing an area of skin approximately 10 cm square under 2.5 cm square gauze pad moistened with 0.5 ml distilled water to one intact skin site of 6 female New Zealand White rabbits.Each treatment site was occluded with Elastoplast elastic adhesive dressing for a four hour period.At the end of the exposure period, the semi-occlusive dressing and gauze pad were removed and washed and animal were scored in accordance with edema erythema formation.Examination of the treated skin was made on Day 1 (i.e. approximately 30 minutes after removal of the patches) andon Days 2, 3 and 4.There was no response to treatment in any animal throughout the observation period.A single semi-occlusive application of Ammonium Molybdate to intact
rabbit skin for four hours elicited no dermal irritation.
The overall irritation index after 4 days of observation was 0.0.Hence, Ammonium molybdate can be considered not irritating to skin.
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