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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study undertaken and reported scientifically but not to GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
not specified
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,4,5,6,7,7-hexachloro-8,9,10-trinorborn-5-ene-2,3-dicarboxylic anhydride
EC Number:
204-077-3
EC Name:
1,4,5,6,7,7-hexachloro-8,9,10-trinorborn-5-ene-2,3-dicarboxylic anhydride
Cas Number:
115-27-5
Molecular formula:
C9H2Cl6O3
IUPAC Name:
3-({3-carboxy-1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hept-5-ene-2-carbonyloxy}carbonyl)-1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hept-5-ene-2-carboxylic acid
Details on test material:
- Name of test material (as cited in study report): Chlorendic anhydride- Analytical purity: 98.81%- Lot/batch No.: 3-12-206

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS- Source: - Age at study initiation: - Weight at study initiation: 2302 to 2557 g- Fasting period before study: - Housing: Hanging wire-mesh cages- Diet: Purina rabbit chow, ad libitum - Water: ad libitum- Acclimation period:ENVIRONMENTAL CONDITIONS- Temperature (°C): - Humidity (%): - Air changes (per hr): - Photoperiod (hrs dark / hrs light): IN-LIFE DATES: From: To:

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE- Area of exposure: - % coverage: - Type of wrap if used: REMOVAL OF TEST SUBSTANCE- Washing (if done): Washed with tepid water- Time after start of exposure: 24 hoursTEST MATERIAL- Amount(s) applied (volume or weight with unit): 10000 and 20000 mg / kg- Concentration (if solution): - Constant volume or concentration used: yes/no- For solids, paste formed: noVEHICLE- Amount(s) applied (volume or weight with unit):- Concentration (if solution):- Lot/batch no. (if required): - Purity:
Duration of exposure:
24 hours
Doses:
10000 and 20000 mg / kg.
No. of animals per sex per dose:
1
Control animals:
yes
Details on study design:
- Duration of observation period following administration: 14 days- Frequency of observations and weighing: At 24 hours and then daily- Necropsy of survivors performed: no- Other examinations performed: clinical signs

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 10 000 - < 20 000 mg/kg bw
Mortality:
Both male rabbits at the 20000 mg / kg dosage level died during the 14 day observation period. None of the other rabbits died.
Body weight:
Apart from the 2 male rabbits at 20000 mg / kg which died, all other rabbits increased in weight during the study.

Applicant's summary and conclusion

Interpretation of results:
relatively harmless
Remarks:
Migrated informationCriteria used for interpretation of results: EU
Conclusions:
Based upon the results obtained, the test material would not be classified as harmful.