Registration Dossier
Registration Dossier
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EC number: 701-171-0 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Non-irritant to the skin or eye based on in vivo results in rabbits
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
TSP/DSP was tested for its skin and eye irritation potential in New Zealand White rabbits following dermal application (RBM study No. 970073, 1997) or ocular conjunctival instillation (RBM study No.970074, 1997). Both studies were key studies of validity 1 according to Klimisch cotation criteria.
No relevant signs of irritation were observed following dermal application of 0.5 mL of the test substance as an occlusive patch for up to 4 hours.
Slight to moderate conjunctival redness was observed within 24 hours of ocular instillation of 0.1 mL in all three animals tested, and fully reversed within 48 hours of exposure.
Therefore, the test item was considered as non irritant to the skin or to the eye.
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Due to the absence of relevant signs of cutaneous irritation following occlusive patch application for up to 4 hours, no classification is warranted for skin irritation according to the criteria of Annex VI Directive 67/748/EEC or UN/EU GHS.
Due to the low severity (grade 1 or 2) and transient nature (mostly reversible within 24 hours of application) of the conjunctival redness noted after ocular instillation, no classification is warranted for eye irritation according to the criteria of Annex VI Directive 67/748/EEC or UN/EU GHS.
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