(1R)-1-[(4R,4aR,8aS)-2,6-bis(3,4-dimethylphenyl)tetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol

Boiling point

Administrative data

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

07 june 2010

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of relevant results.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2010

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling point/boiling range)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

Date of inspection: 15th September 2009. Date of signature: 26th November 2009

Type of method:

differential scanning calorimetry

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

413-110-2

EC Name:

-

Cas Number:

135861-56-2

Molecular formula:

C24H30O6

IUPAC Name:

(1R)-1-[(4R,4aR,8aS)-2,6-bis(3,4-dimethylphenyl)tetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol

Results and discussion

Boiling point

Boiling pt.:

> 355 °C

Atm. press.:

101.31 kPa

Decomposition:

yes

Decomp. temp.:

ca. 355 °C

Any other information on results incl. tables

As the residue was only a thin film after the determinations and the thermograms showing an endotherm, this suggested that boiling had occured. Two investigative determinations under air and nitrogen up to 300°C (573 K) were performed. The residues for thse was off white with a slight brown colouring to the edges. This suggested that slight decompositin had occured but confirmed that the majority of the decomosition occurred above 300°C (573 K). It was therefore considered that the test item had not boiled, but the loss of sample had been due to boling of decomposition products. The broad endotherm was more indicative of gradual decomposition as temperature increases because pure substances usually boil with a narrow endotherm.

An estimation was performed using an ada[tation of the Stein and Brown Method, MPBPWIN version 1.43 (© 2000 US Environmental Protection Agency), which calculated a value of 543.10°C.

As a result of the low rate of enthalpy change during decomposition, the onset temperature can only be approximated.

Similar thermographic profiles were obtained using air and nitrogen atmospheres; this indicates that the observed decomposition in both determinations is probably thermal and not oxidative.

A determination at reduced pressure was not performed as experience has shown that no further useful information is obtained for solid test items which decompose prior to boiling at atmospheric pressure.

Applicant's summary and conclusion

Conclusions:

The test item has been determined to decompose from approximatelt 355°C (628 K) at approximately 101.31 kPa.

Executive summary:

The determination of boling temperature was carried out by differential scanning calorimetry (DSC) using the procedure specified in ASTM E537-86 designed to be compatible with Method A2 Boiling Temperatyre of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 103 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

The test item has been determined to decompose from approximately 355°C (628 K) at approximately 101.31 kPa.