Registration Dossier
Registration Dossier
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EC number: 421-450-8 | CAS number: 154702-15-5
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The REACH regulation mentions the following for toxicokinetics: Assessment of the toxicokinetic behaviour of the substance needs to be done to the extent that can be derived from the relevant available information. It is important to note that Iscotrizinol (USAN], Synonym (diethylhexyl butamido triazone) is an organic compound predominantly used in sunscreens to absorb UVA and UVB radiations.
Thus, the oral ingestion, distribution, metabolism and excretion of the chemical is unlikely. For dermal absorption, certain European studies conducted to review the dermal absorption potential indicate very low degree of percutaneous absorption when the radioactive form of the chemical was used on living human skin samples (ex-vivo).
Analysis of the other toxicity data in the review study conducted on Iscotrizinol led to the conclusion that the compound exhibited a sufficiently high margin of safety.
Thus, the end point of toxico-kinetics was considered for waiver since it can be concluded that the bio-accumulation potential for this chemical is low
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
The REACH regulation mentions the following for toxicokinetics: Assessment of the toxicokinetic behaviour of the substance needs to be done to the extent that can be derived from the relevant available information. It is important to note that Iscotrizinol (USAN], Synonym (diethylhexyl butamido triazone) is an organic compound predominantly used in sunscreens to absorb UVA and UVB radiations.
Thus, the oral ingestion, distribution, metabolism and excretion of the chemical is unlikely. For dermal absorption, certain European studies conducted to review the dermal absorption potential indicate very low degree of percutaneous absorption when the radioactive form of the chemical was used on living human skin samples (ex-vivo).
Analysis of the other toxicity data in the review study conducted on Iscotrizinol led to the conclusion that the compound exhibited a sufficiently high margin of safety.
Thus, the end point of toxico-kinetics was considered for waiver since the bioaccumulation potential of this chemical can be considered to be low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
