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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Basic data given. The justification for the Read Across approach has been attached to the Section 13

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Tetrabromobisphenol A and Derivatived (Environmental health criteria ; 172).
Author:
G.J. van Esch
Year:
1995
Bibliographic source:
World Health Organization; IPCS
Reference Type:
secondary source
Title:
PE-68, Bis (2,3-dibromopropyl ether) of tetrabromobisphenol A
Author:
Great Lakes ChemicalCorporation
Year:
1987
Bibliographic source:
Unpublished report

Materials and methods

Principles of method if other than guideline:
No available information on the method used.
GLP compliance:
not specified
Test type:
other: No data available

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
Application to closely clipped intact skin
Duration of exposure:
24 hours
Control animals:
not specified
Details on study design:
Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 20 000 mg/kg bw
Based on:
not specified
Remarks on result:
other: No information on confidence level

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information According to the CLP Regulation Criteria used for interpretation of results: EU
Conclusions:
LD50 > 20000 mg/kg bw
Executive summary:

Method

The evaluation of acute dermal toxicity reported from Great Lakes Chemical Corporation (1987)[1] in the WHO publication[2] has been considered in order to complete the assessment.

The test has been conducted in mice; the substance has been applied on closely clipped intact skin for 24 hours. The animals have been observed for 14 days after application. No further information on the method used is available.

Results

The dermal LD50 reported in this reviews on the Similar Substance 01 is greater than 20000 mg/kg bw.

 

[1] Great Lakes Chemical Corporation (1987) Summaries of toxicity data. PE-68, Bis(2,3-dibromopropyl ether) of tetrabromobisphenol A. West Lafayette, Indiana, Great Lakes Chemical Corporation (Unpublished   report submitted to WHO by the Brominated Flame Retardant Industry Panel).

 

[2]World Health Organization (WHO, Geneva, 1995); Dr. G.J. van Esch “Tetrabromobisphenol A and Derivatived” (Environmental health criteria; 172)