Registration Dossier
Registration Dossier
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EC number: 236-675-5 | CAS number: 13463-67-7
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well-documented publication. However, this in vitro test system is considered of restricted relevance for mutagenicity assessment of TiO2.
Data source
Reference
- Reference Type:
- publication
- Title:
- Enhancement of Viral Transformation for Evaluation of the Carcinogenic or Mutagenic Potential of Inorganic Metal Salts.
- Author:
- Casto, B.C. et al.
- Year:
- 1 979
- Bibliographic source:
- Cancer Research 39, 193-198
Materials and methods
- Type of study / information:
- Mutagenicity
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Study only reports on isolated mechanistic investigations.
Enhancement of viral transformation in Syrian hamster embryo cells (HEC) as an in vitro test of potential carcinogens and mutagens. - GLP compliance:
- no
Test material
- Reference substance name:
- Titanium dioxide
- EC Number:
- 236-675-5
- EC Name:
- Titanium dioxide
- Cas Number:
- 13463-67-7
- Molecular formula:
- O2Ti
- IUPAC Name:
- dioxotitanium
Constituent 1
Results and discussion
Any other information on results incl. tables
38 metal salts have been studied in the viral enhancement assay. Those chemicals which are carcinogenic or mutagenic increased the frequency of adenovirus transformation.
Applicant's summary and conclusion
- Conclusions:
- TiO2 belongs to the 10 compounds which were negative in enhancement of viral transformation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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