Registration Dossier
Registration Dossier
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EC number: 231-441-9 | CAS number: 7550-45-0
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The hydrolysis transformation products of titanium tetrachloride do not exhibit chronic toxicity.
Key value for chemical safety assessment
Additional information
Titanium tetrachloride rapidly hydrolyses in water resulting in the formation of titanium dioxide (CAS 13463-67-7). The release of hydrogen chloride (CAS 7647-01-0) acid is assumed not causing an increase in acidity in the dose levels relevant for chronic exposure scenarios. Anyhow acidity is not true toxicity and not relevant for the derivation of environmental threshold levels. Thus the hazard assessment bases on titanium dioxide effects.
The assumption of absent chronic fish toxicity of titanium dioxide is supported by the low bioaccumulation tendency (Frederici et al 2007), the absence of acute toxicity at high loading rates and by the experimental data of Beim et al (1982). The latter study reports no effect to early life stages of minnows after 30 d exposure in saturated solution together with undissolved microdisperse matter in excess, but is not poorly documented. Together with the above mentioned evidence a sufficient base for assessing the chronic effects of titanium tetrachloride are given.
It is concluded that the titanium tetrachloride hydrolysis transformation products do not exhibit chronic effects at the level of their water solubility in addition with undissolved microdisperse matter in excess.
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