Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-266-5 | CAS number: 1317-35-7
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of chronic high-level manganese exposure on male behaviour in the Japanese Quail (Coturnix coturnix japonica)
- Author:
- Laskey JW and Edens FW
- Year:
- 1 985
- Bibliographic source:
- Poultry Science, 64: 579-584
Materials and methods
- Type of study / information:
- Reproductive/developmental toxicity
- Principles of method if other than guideline:
- The study was designed to determine whether chronic dietary Mn exposure at high dietary levels would retard reproductive development in the Japanese quail. Male Japanese quail were chronically exposed to 5000 ppm manganese (Mn) as particulate Mn3O4 in their diet from hatching to 75 days of age.
- GLP compliance:
- no
Test material
- Reference substance name:
- Trimanganese tetraoxide
- EC Number:
- 215-266-5
- EC Name:
- Trimanganese tetraoxide
- Cas Number:
- 1317-35-7
- Molecular formula:
- Mn3O4
- IUPAC Name:
- trimanganese tetraoxide
- Details on test material:
- Mn3O4
Constituent 1
Results and discussion
Any other information on results incl. tables
No decrements in growth or in other indices of general toxicity were noted. There were significant (P<0.05) age-related increases in general locomotor activity in the control group, although no significant (0.05 < P < 0.10) increases were seen in the Mn-treated group. Both control and Mn-treated groups had significant (P<0.5) age-related increases in aggressive behaviour with an overall significant (P<0.05) treatment-related depression. Serum testosterone concentration was only slightly depressed (0.5 < P < 0.01) in the 75 day-old, Mn-treated quail. Both the control and Mn-treated qualil had higher liver Mn concentrations than previously Mn in their livers than similarly treated rodents.
Applicant's summary and conclusion
- Conclusions:
- This study indicated that the Japanese quail were not sensitive to Mn3O4 exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
