Registration Dossier
Registration Dossier
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EC number: 203-400-5 | CAS number: 106-46-7
Immunotoxicity
Administrative data
Description of key information
There is no evidence of an immunotoxic potential based on the repeated dose toxicity studies, as well as in an immunotoxicity study in guinea pigs. In that study groups of 10 male Hartley strain guinea pigs were exposed to 0 (control), 2 or 50 ppm 1,4-dichlorobenzene (0, 12.0 or 300.5 mg/m3) for 12 wk. During exposure, they were sensitized with ovalbumin twice. The IgE, IgG and IgM antibody titers against ovalbumin showed no significant difference between control (air exposed) and 1,4-dichlorobenzene groups. There was no significant difference in the thymus or spleen weight between the control and 1,4-dichlorobenzene groups, nor was there any significant difference in the total or differential leucocyte count (Suzuki 1991).
Key value for chemical safety assessment
Effect on immunotoxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Justification for classification or non-classification
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