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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Toxicity to reproduction: other studies

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Administrative data

Endpoint:
toxicity to reproduction: other studies
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The result is sourced from secondary literature (previous IUCLID data set). The original reference was not available for review and no further information is available.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
In vitro relative binding affinity assay (RBA)
GLP compliance:
yes
Type of method:
other: receptor binding assay (RBA)

Test material

Constituent 1
Chemical structure
Reference substance name:
Decamethylcyclopentasiloxane
EC Number:
208-764-9
EC Name:
Decamethylcyclopentasiloxane
Cas Number:
541-02-6
Molecular formula:
C10H30O5Si5
IUPAC Name:
2,2,4,4,6,6,8,8,10,10-decamethyl-1,3,5,7,9,2,4,6,8,10-pentoxapentasilecane

Test animals

Species:
other: Not applicable, in vitro study
Strain:
other: Not applicable, in vitro study

Administration / exposure

Route of administration:
other: Not applicable, in vitro study
Vehicle:
other: filtered air
Analytical verification of doses or concentrations:
yes
Details on analytical verification of doses or concentrations:
160 ppm
Duration of treatment / exposure:
No data
Frequency of treatment:
No data
Duration of test:
No data
Doses / concentrations
Remarks:
Doses / Concentrations:
160 ppm
Basis:
nominal conc.
No. of animals per sex per dose:
NA
Control animals:
other: NA

Results and discussion

Effect levels

Dose descriptor:
NOAEC
Basis for effect level:
other: D5 was not able to displace the radiolabelled estradiol, indicating that this test article was unable to directly compete for the active site of the estrogen receptor alpha.
Remarks on result:
not determinable
Remarks:
no NOAEC identified

Observed effects

The ability of D5 to compete for the estrogen receptor-alpha was evaluated using the relative binding affinity assay (RBA). Over the course of three separate experiments, there was no displacement of the radiolabelled 3H-estradiol, indicating that under these in vitro conditions D5 is not competing directly for the binding site of the estrogen receptor-alpha.

Applicant's summary and conclusion

Conclusions:
Under these in vitro conditions, the cyclosiloxane, D5 was not able to displace the radiolabelled estradiol, indicating that this test article was unable to directly compete for the active site of the estrogen receptor alpha.