Registration Dossier

Administrative data

Description of key information

Older proprietary studies of skin and eye irritation are available; additional published summary data are also available.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Skin irritation/corrosion

Phosphorus trichloride was found to cause corrosive effects in a skin irritation study (Imlay, 1977). Similar effects are reported in studies by Randall & Robinson (1990), Molodkina (1973) and Leist & Weigand (1978). A study summary (Pauluhn, 1984) reports corrosive effects within 60 second of the dermal application of 100 ul phosphorus trichloride.

Eye irritation

Severe reactions seen in an eye irritation study (Imlay, 1977) were confirmed in other studies by Randall & Robinson (1990), Molodkina (1973) and Leist & Weigand (1978).


Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: highly irritating

Justification for classification or non-classification

Phosphorus trichloride is listed on Annex I of the Dangerous Substances Directive (67/548/EEC) with classification as 'Corrosive' (R35) 'Causes severe burns'. No change to this classification is proposed. Classification with (R41) 'Risk of serious damage to eyes' is implicit.