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EC number: 204-263-4 | CAS number: 118-60-5
2-Ethylhexyl salicylate can be well absorbed via the dermal and the oral route of exposure. Inhalative exposure is not relevant due to low vapour pressure. No accumulation in the body is expected due to efficient metabolic pathways and formation of soluble degradation products (salicylic acid and 2-ethylhexanol) with established elimination routes.
It is concluded that the absorption of 2-ethylhexyl salicylate via the dermal route is very low (3%), while it is well absorbed via the oral route (100% absorption assumed). Following absorption, 2-ethylhexyl salicylate is metabolized to salicylic acid and 2-ethylhexanol rapidly. Salicylic acid is mainly excreted by renal excretion as an unchanged chemical entity or after conjugation with glycine as salicyluric acid. 2-Ethylhexanol is metabolized following metabolic pathways of alcohols with its degradation products mainly excreted in respiratory CO2, via faeces and urine. No accumulation in the body is expected due to efficient metabolic pathways and formation of soluble degradation products (salicylic acid and 2-ethylhexanol) with established elimination routes.
Due to low vapor pressure (1.8E-4hPa at 20 °C, Symrise) and high boiling point (> 300 °C, Intertek ASG), the inhalation route is not considered to be a relevant exposure route to human for 2-ethylhexyl salicylate.
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